Results 241 to 250 of about 1,691,740 (308)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

IL-22 promotes the establishment of chronic gammaherpesvirus infection by supporting the germinal center response. [PDF]

PLoS Pathog
Majeed ST, Bradford SM, Jondle CN.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Factors associated with access channels and satisfaction with health science popularization among health lifestyle instructors. [PDF]

Front Public Health
Chen XP, Zhuang SS, Zhang T, Wei LW, Ji SY, Gou LL, Yang HF.   +6 more
europepmc   +1 more source

Establishing a Dedicated Body Contouring Fellowship: Rationale, Structure, and a Framework for Subspecialty Training. [PDF]

Aesthet Surg J Open Forum
Ahmed MB, Al-Qahtani A.
europepmc   +1 more source

Timing of Do-Not-Resuscitate Order Establishment Varies by Illness Trajectory and Clinical Context in Children Receiving Palliative Care: A Retrospective Cohort Study. [PDF]

Cureus
Javadi S, Espiritu I, Leung TM, Karam O, Siegel LB.   +4 more
europepmc   +1 more source

Nuclear Medicine in IRAQ: From a Pioneering Past to Future Progress. [PDF]

J Multidiscip Healthc
Abdlkadir AS, Al-Hissoni M, Hassan IM, Al-Adhami MN, Al-Haydar Z, Al-Nahhas A, Al-Attar R, Al-Badr A, Al-Hussaini KS, Al-Shammaa M, Al-Tuma RR, Al-Alawi H, Khalaf AN, Anwar FM, Al-Ruwaishedi QS, Al-Thabhawee M, Al-Adhami D, Al-Ibraheem A.   +17 more
europepmc   +1 more source

Harnessing synthetic microbial communities for desert vegetation restoration. [PDF]

Synth Syst Biotechnol
Zhang P, Wang H, Jia X, Zhang X.
europepmc   +1 more source