Results 51 to 60 of about 309,120 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A field-based indicator for determining the likelihood of Ixodes scapularis establishment at sites in Ontario, Canada.

PLoS ONE, 2018
The emergence of the vector Ixodes scapularis in Ontario, Canada poses a significant public health risk. Both passive and active surveillance approaches have been employed by public health professionals (i.e., government employees) to monitor for the ...
Katie M Clow, Nicholas H Ogden, L Robbin Lindsay, Curtis B Russell, Pascal Michel, David L Pearl, Claire M Jardine   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Disentangling plant establishment in sandy coastal systems: biotic and abiotic factors that determine Allagoptera arenaria (Arecaceae) germination

Acta Botânica Brasílica, 2017
Germination rate and establishment success of plants in harsh environments depend on the ability of seeds to withstand unfavorable environmental conditions and avoid predators.
Luis Fernando Tavares de Menezes, Francisco I. Pugnaire, Gloria Matallana, Felipe Cito Nettesheim, Daniel Costa de Carvalho, Eduardo Arcoverde de Mattos   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effect of Seed Priming on Germination Properties and Seedling Establishment of Cowpea (Vigna sinensis)

Notulae Scientia Biologicae, 2011
Early emergence and stand establishment of cowpea are considered to be the most important yield-contributing factors in rainfed areas. Laboratory tests and afield experiment were conducted in RCB design in 2011 at a research farm in Ramhormoz, Iran, to ...
Hamdollah ESKANDARI, Kamyar KAZEMI
doaj   +3 more sources

The establishment of a scientific field: The history of reindeer husbandry research in Sweden 1900-1970

Rangifer, 2011
The focus of this article is the development of reindeer husbandry research as a scientific field within the natural sciences, 1900-1970. Up until after World War II, research within this field was mostly carried out by social scientists, while it was ...
Patrik Lantto
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Field validation of listings of food stores and commercial physical activity establishments from secondary data

International Journal of Behavioral Nutrition and Physical Activity, 2008
Background Food- and activity-related establishments are increasingly viewed as neighbourhood resources that potentially condition health-related behaviour.
Daniel Mark, Paquet Catherine, Kestens Yan, Léger Karine, Gauvin Lise   +4 more
doaj   +1 more source