Results 161 to 170 of about 182,434 (289)

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Thermal Cyclotrimerization Bridges Polymer‐Filler Interfaces for High‐Performance CO2 Separation Membranes

Advanced Science, EarlyView.
Thermal cyclotrimerization of nitriles converts interfacial discontinuity in MAF‐stu‐1/PIM‐1 MMMs into a continuity‐enhanced junction. Triazine–Zn2+ coordination between TR‐PIM chains and MAF‐stu‐1, together with hydrogen bonding and π–π stacking, lowers interfacial tension and builds selective CO2 pathways, enabling > 10 000 barrer CO2 permeability ...
Zhihong Lin, Kaifang Wang, Ziyi Yuan, Jiali Tang, Xiaozhen Liu, Liu Chen, Lu Shao, Xuezhong He   +7 more
wiley   +1 more source

Quasi-Simultaneous Detection of Ammonia and Nitrous Oxide by Photoacoustic Phase-Resolved Method: A Proof-of-Concept. [PDF]

Anal Chem
Santos DDS, Mota L, Lima GR, da Matta EC, Alvarenga TL, Bahr MS, Esquef IA, Wolff M, da Silva MG.   +8 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Colonic Intussusception in Adults: A Case Report of an Unusual Cause of Abdominal Pain. [PDF]

Cureus
Bustamante Sánchez LF, Rivera Jiménez EJ, Vela Martínez MI, Castro Segovia A, Cortés Sánchez JL.   +4 more
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Elucidating Structural Disorder in a Polymeric Layered Material: The Case of Sodium Poly(heptazine imide) Photocatalyst. [PDF]

Nano Lett
Khaykelson D, Diab GAA, Cohen SR, Kashti T, Bendikov T, Pinkas I, Teixeira IF, Tarakina NV, Houben L, Rybtchinski B.   +9 more
europepmc   +1 more source

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, EarlyView.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source

Robust Smart Superhydrophobic Cilia

Advanced Science, EarlyView.
To date, ciliated surfaces cannot withstand mechanical damage because cilia/wires are inherently fragile. By aligning magneto‐responsive, flexible, superhydrophobic microwires on the sidewall of vertical frames, the frames act as armors to protect microwires from mechanical damage; when needed, the microwires re‐align uprightly under a magnet field to ...
Chuanqi Wei, Baixue Li, Yimeng Zhang, Oleg V. Gendelman, Youhua Jiang   +4 more
wiley   +1 more source

Correction: Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia. [PDF]

Front Public Health
Lewandrowski KU, Blum K, Lewandrowski APL, Thanos PK, Pinhasov A, Sharafshah A, Baron D, Gold MS, Dennen CA, Elman I, Bowirrat A, Modestino EJ, Zeine F, Jafari N, Sunder K, Makale MT, Giordano J, Gondre-Lewis MC, Lindenau M, Fuehrlein BS, Badgaiyan RD, Levin C, Schmidt SL, Fiorelli RKA.   +23 more
europepmc   +1 more source