Results 141 to 150 of about 1,027,919 (286)

O DASP e o combate à ineficiência nos serviços públicos: a atuação de uma elite técnica na formação do funcionalismo público no Estado Novo (1937-1945).

Revista Brasileira de História & Ciências Sociais, 2015
O Departamento Administrativo do Serviço Público (DASP) foi um órgão criado em 1938 pelo governo de Getúlio Vargas (1930-1945), com o objetivo de diminuir a ineficiência do funcionalismo público federal e reorganizar a administração pública.
Fernanda Lima Rabelo
doaj  

Localized Temperature Monitoring in Mouse Brain during Light Delivery via a Non‐Planar Tapered Fiber‐Integrated µRTD Sensor

Advanced Materials, EarlyView.
We report a multifunctional tapered optical fiber integrating a conformal micro‐resistance temperature detector (µRTD) for local, real‐time thermometry during optical stimulation. The platform combines light‐delivery and temperature sensing within a minimally invasive footprint, enabling detection of sub‐degree cortical heating under representative ...
Antonio Balena, Marco Bianco, Barbara Spagnolo, Muhammad Fayyaz Kashif, Alberto Bramati, Massimo De Vittorio, Ferruccio Pisanello   +6 more
wiley   +1 more source

Actuation of Cell Layers in Three Dimensions

Advanced Materials, EarlyView.
ABSTRACT The alignment of fibers and cells in living tissues affect their mechanical properties and functionality. In this context, one can draw an analogy between tissues and nematic liquid crystal elastomers. We explore this analogy by growing fibroblasts on 2D‐patterned substrates and observing the contraction of cell sheets upon detachment from the
Kirsten Endresen, Aniruddh Murali, Birte C. Geerds, Grecia M. Valenzuela Portillo, Maria Bloksgaard, Daniel J.G. Pearce, Francesca Serra   +6 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Reconnaissance Peptide Labeling Grain Boundary of Chemically Grown MoS2 Polycrystalline Monolayer

Advanced Materials Technologies, EarlyView.
Self‐assembled peptides on substrates, through adsorption and aggregation, offer an alternative way to label grain boundaries in chemically grown single‐layer polycrystalline MoS2. During an early nucleation step, peptides preferentially bind to grain boundaries.
Linhao Sun, Jinhua Hu
wiley   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

A política criminal-migratória no Estado Novo:

Revista Espaço Acadêmico, 2020
No presente artigo, estuda-se a política migratória no Estado Novo, marcado pela repressão do migrante internacional, o estrangeiro indesejado e constituído enquanto inimigo a ser neutralizado, como necessidade de manutenção da segurança nacional e em decorrência de critérios étnico-raciais.
openaire   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

[The Instituto de Investigação Científica de Angola: from the New State to independence, 1955-1975]. [PDF]

Hist Cienc Saude Manguinhos
Ferreira SS, Matos D.
europepmc   +1 more source