Results 51 to 60 of about 1,021,999 (290)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Portaria de Credenciamento ENFAM n. 233 de 20 de agosto de 2015 [PDF]

, 2015
Credencia o curso "O Novo Código de Processo Civil" promovido pela Escola da Magistratura do Estado do Rio de ...
Escola Nacional de Formação e Aperfeiçoamento de Magistrados (Brasil) (ENFAM)
core   +4 more sources

O sistema eleitoral no Estado Novo: o papel do Presidente da República na estabilidade ou na ruptura do regime criado pela Constituição de 1933

Revista da Faculdade de Letras. Série de História, 2019
The establishment of the Republic, on 5 October 1910, established the figure of the President of the Republic as the Head of the Nation and the main political figure of the country.
Ana Sofía Matos Ferreirao
doaj   +1 more source

Portaria de Credenciamento ENFAM n. 105 de 11 de maio de 2015 [PDF]

, 2015
Credencia o curso "O Novo Código de Processo Civil" promovido pela Escola da Magistratura do Estado do Rio de ...
Escola Nacional de Formação e Aperfeiçoamento de Magistrados (Brasil) (ENFAM)
core   +1 more source

Estado Novo: "República corporativa"

Revista de História das Ideias, 2006
Res_por:Ao contrario do Fascismo italiano, o sistema politico portugues chamado "Estado Novo", projectado e construido por Oliveira Salazar, com a colaboracao de uma elite de formacao e tendencias politicas diversas, numa logica de convergencia, de "terceira via", social e nacionalista, foi uma Republica.
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

O intelectual brasileiro e o argumento do cangaço na década de 1930

Revista do Instituto de Estudos Brasileiros, 2019
RESUMO O cangaço foi tema recorrente de jornais, livros, músicas, filmes e peças teatrais durante toda a primeira metade do século XX. Neste artigo, buscaremos comparar os discursos sobre o assunto veiculados pela imprensa brasileira contemporânea ao ...
Pedro Lotti Carvalho Dias
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source