Results 51 to 60 of about 16,315 (293)

Imaginários turísticos no Estado Novo português

PASOS Revista de Turismo y Patrimonio Cultural, 2015
Em 1940, António Ferro disse a um grupo de profissionais de turismo, que visitavam o Gabinete Oficial de Propaganda, que Portugal era uma exposição impressionante do turismo nacional.
Cândida Cadavez
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Receção mediática e história oral: operárias da Covilhã no Estado Novo [PDF]

, 2014
O período do Estado Novo (1933-1974), caracterizado por um sistema social fortemente patriarcal, assistiu também à entrada de novos meios de experiência simbólica, a rádio e da televisão, na vida das mulheres.
Carvalheiro, José Ricardo, Tomás, Diana Gonçalves   +1 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

As bandeiras no Estado Novo

Revista Espacialidades, 2018
Este artigo tem por objetivo discutir a respeito do conceito de biodemocracia desenvolvido por Cassiano Ricardo na obra Marcha para Oeste: A influência da “Bandeira” na formação social e política do Brasil. É nesta obra que o autor formula suas ideias a respeito da existência de uma democracia racial tipicamente brasileira, pautada pela convivência ...
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Educação e estado novo em Minas Gerais [PDF]

, 2011
Resenha do livro PEIXOTO, A. M. C. Educação e estado novo em Minas Gerais.
dos Santos, Hercules Pimenta, Hercules Pimenta dos Santos   +1 more
core  

Almir de Andrade: intelectual do Estado Novo

, 2015
O objetivo deste artigo é analisar o perfil intelectual de Almir de Andrade como ideólogo do Estado Novo e editor da revista Cultura Política, publicada pelo DIP entre os anos 1941 e 1945.
Paiva, Valéria, Valéria Paiva
core   +1 more source