Results 51 to 60 of about 4,659,210 (298)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Tradução e Autocensura no Estado Novo: o Caso de Jane Eyre [PDF]

, 2023
De um modo geral, em regimes autoritários, a prática da tradução é percecionada de forma negativa, uma vez que intensifica o contacto com o exterior e promove uma maior acessibilidade cultural, ambos fatores considerados “perigosos” do ponto de vista
Fernandes, Rita Nazaré Dias Novo
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

O pluralismo jurídico e a sua emergência no novo constitucionalismo latino-americano [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.Os novos textos constitucionais, fruto das lutas populares que se estenderam pelas últimas décadas do século XX e início do século XXI, evidenciaram a ...
Elling, Matheus Henrique
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O sistema eleitoral no Estado Novo: o papel do Presidente da República na estabilidade ou na ruptura do regime criado pela Constituição de 1933

Revista da Faculdade de Letras. Série de História, 2019
The establishment of the Republic, on 5 October 1910, established the figure of the President of the Republic as the Head of the Nation and the main political figure of the country.
Ana Sofía Matos Ferreirao
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

O intelectual brasileiro e o argumento do cangaço na década de 1930

Revista do Instituto de Estudos Brasileiros, 2019
RESUMO O cangaço foi tema recorrente de jornais, livros, músicas, filmes e peças teatrais durante toda a primeira metade do século XX. Neste artigo, buscaremos comparar os discursos sobre o assunto veiculados pela imprensa brasileira contemporânea ao ...
Pedro Lotti Carvalho Dias
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

O paradigma do estado e mercado fortes: o desenvolvimentismo no Brasil contemporâneo [PDF]

, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.Após duas décadas de hegemonia econômica, política e acadêmica o arcabouço teórico e prático neoliberal não obteve sucesso em promover o crescimento econômico e ...
Reis, Andreia Cristina dos
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source