Results 121 to 130 of about 9,030,402 (306)
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera +20 more
wiley +1 more source
Overall program design: Chikaskia, Indian Hills and Golden Belt Regional Planning Commissions [1974]
, 1974 The Chikaskia Region includes the following counties: Kingman, Harper and Sumner. The Indian Hills Region includes the following counties: Kiowa, Comanche, Pratt and Barber.
Kansas Center for Regional Progress
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch +5 more
wiley +1 more source
Análise do Controle Interno exercido pelos contadores nas Secretarias de Desenvolvimento Regional do Estado de Santa Catarina [PDF]
, 2010 TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Ciências ContábeisO controle interno faz parte das atividades normais da Administração Pública e tem como função acompanhar a execução dos atos para verificar se ...
Klein, Heloise
core
Revista Insignare ScientiaEsse artigo tem como foco o papel do brincar para o desenvolvimento psíquico da criança em idade pré-escolar. O objetivo principal foi compreender os avanços no desenvolvimento psíquico da criança proporcionados pelo ato de brincar, permitindo que ela ...
Débora Kélli Freitas de Melo +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
Revista Brasileira de Geriatria e GerontologiaO processo de envelhecimento é caracterizado por várias modificações no organismo, que podem causar alterações no efeito de certos medicamentos, tornando-os inapropriados para idosos por falta de eficácia terapêutica ou por apresentarem efeitos adversos ...
Cristiane Schmalz Bueno +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source