Results 131 to 140 of about 48,696 (263)

[Incidence of the progression and remission of cognitive decline in older adults]. [PDF]

Rev Med Inst Mex Seguro Soc
González-Sotelo DA, Bermúdez-Rojas AY, Berumen-Lechuga MG, Castro-Leyva V, Bobadilla-Serrano ME, Julián-Hernández YJ, Espinosa-Lugo M, Juárez-González J, Hernández-Esquivel A, Camacho-Ruiz J, Sánchez-Arenas R.   +10 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

[Impact of sarcopenia risk on the functionality of older adults after emergency surgery]. [PDF]

Rev Med Inst Mex Seguro Soc
Martínez-Magaña JF, Medina-García JI, Millán-Pacheco C A, Camacho-Ruíz J, Ricarte-Almeida ER, Arianna RB.   +5 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Early-life environmental enrichment reduces anxiety and induces sex-dependent neuroplasticity in hypothalamic oxytocin and vasopressin neurons. [PDF]

J Neuroendocrinol
Muniz SCA, Nani JVS, Marciano NJDS, Souza RDN, Laureano-Melo R, Cortes WDS, Rocha FFD, Mecawi AS.   +7 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

[Case report of human myiasis caused by Cochliomyia hominivorax in Mexico]. [PDF]

Rev Med Inst Mex Seguro Soc
Hernández-Peláez DK, De la Mora-López CF, Vega-Dovalí M.   +2 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

[Clinical determinants of levothyroxine dosage adjusted for various body weights]. [PDF]

Rev Med Inst Mex Seguro Soc
García-Cabello R, Melacio-Rodríguez MA.   +1 more
europepmc   +1 more source