Results 31 to 40 of about 801,293 (296)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Revista de Derecho Político, 2012 El proceso constituyente de los nuevos Estados hispanoamericanos se inaugura con los movimientos revolucionaros independentistas de la América española en 1810.
Allan R. Brewer-Carías
doaj +1 more source
Los intereses nacionales de Estados Unidos en América Latina
Foro Internacional, 1982 Laurence Whitehead
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
La formación del territorio del noroeste del río Ohio en Estados Unidos (1787) y la formación de los territorios nacionales en Argentina (1884). Influencias, semejanzas y diferencias [PDF]
Estudios Socioterritoriales: Revista de Geografía, 2010 A partir de comprender la influencia del modelo territorial norteamericano en la constitución del territorio de la Argentina, el artículo analiza la formación del Territorio del Noroeste de Río Ohio de los Estados Unidos (1787) y la constitución de los ...
Perla Zusman
doaj
Migración, integración y nacionalismo: reflexiones para una ciudadanía inclusiva
Migraciones, 2014 El presente texto reflexiona sobre el concepto de integración social, vinculándolo a los debates sobre ciudadanía en el marco de Estados democráticos.
Menara Lube Guizardi
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
LA PROBLEMÁTICA DE LAS SUCESIONES TRANSFRONTERIZAS EN EUROPA [PDF]
Crónica Tributaria, 2014 La disparidad normativa de las legislaciones nacionales de los Estados miembros de la Unión Europea en materia de sucesiones está provocando posibles problemas de mercado interior.
Javier Martín Román +1 more
doaj
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source