Results 51 to 60 of about 59,362 (294)

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

open access: yesAdvanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang   +10 more
wiley   +1 more source

Complete Mouth Rehabilitation and Gastroesophageal Reflux Disease: Conventional and Contemporary Treatment Approaches [PDF]

open access: yes, 2017
This report describes the diagnosis and prosthodontic management of 2 patients with a history of chronic gastroesophageal reflux disease and worn dentition. Different treatment approaches were used for oral rehabilitation.
Chronopoulos, Vasilios   +4 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

open access: yesAdvanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei   +11 more
wiley   +1 more source

Low Molecular Weight Hyaluronic Acid Combined with Six Amino Acids for Female Genital Well-Being: A Multicenter Prospective Pilot Study

open access: yesWomen
Genitourinary syndrome of menopause (GSM), which includes vulvovaginal atrophy (VVA) and other bothersome genitourinary symptoms, affects over half of postmenopausal women and has a considerable impact on quality of life. This study aimed to evaluate the
Elena Fasola   +8 more
doaj   +1 more source

The assessment of golden proportion in primary dentition

open access: yesContemporary Clinical Dentistry, 2020
Background: Golden proportion is a constant ratio that exists in nature, responsible for the esthetic appeal of parts in the human body. The study was aimed to assess the existence of golden proportion in primary dentition by evaluating the average width
Deepika Mamidi   +4 more
doaj   +1 more source

Limitations on applying Peircean semeiotic. Biosemiotics as applied objective ethics and esthetics rather than semeiotic. [PDF]

open access: yes, 2005
This paper explores the critical conditions of such semiotic realism that is commonly presumed in the so-called Copenhagen interpretation of biosemiotics. The central task is to make basic biosemiotic concepts as clear as possible by applying C.S. Peirce’
Vehkavaara, Tommi
core   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy   +8 more
wiley   +1 more source

Considerações sobre o ator: uma introdução ao projeto nietzschiano da fisiologia da arte Considerations of actor: an introduction to the nietzschian project of physiology of art

open access: yesTrans/Form/Ação, 2007
Contemporâneo ao projeto da transvaloração de todos os valores, o esboço de uma "fisiologia da arte" adquire um papel central nos últimos escritos de Nietzsche.
Ernani Chaves
doaj   +1 more source

A Technique for Duplicating a Fixed Complete Denture [PDF]

open access: yes, 2008
The fixed implant prosthesis often requires repair due to fracture and/or wear of acrylic resin teeth. Repair of such a prosthesis, although simple, requires retaining the prosthesis to be revised in the laboratory.
Monaco, Jr., Edward A., Prasad, Soni
core   +1 more source

Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity

open access: yesAdvanced Science, EarlyView.
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini   +8 more
wiley   +1 more source

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