Results 131 to 140 of about 2,627,208 (304)

On the Marginal Value of a Fish: Some Evidence from a Steelhead Fishery

open access: yes
Policymakers and other interested parties frequently request information on the recreational value of a fish. Although fishing valuation studies date back at least 25 years, most studies focus on the average value of a fish.
Johnson, Neal S., Adams, Richard M.
core  

Measuring total value of a river cleanup

open access: yes, 2003
The paper estimates the total value for the community of the cleanup of the Buriganga River in Bangladesh. Dhaka, the capital of Bangladesh, was developed on the bank of the Buriganga River in the early 1600s.
Alam, Khorshed, Marinova, Dora
core  

Utility Value Sets for Sri Lanka: A Case For Economic Evaluations in South Asia

open access: yes, 2016
Objectives Economic evaluations to inform decision making in health resource allocations are scarce in the low and middle income countries, including in Sri Lanka.
Scuffham, P   +3 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The enterprise value in assessing the methodological approach

open access: yesХабаршысы. Экономика сериясы, 2016
The task of business valuation occurs at different stages of development of the enterprise, and never loses its relevance. Therefore enterprise value evaluation techniques, frequently used in practice.
Zh. A. Askarova
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Application of Nationality-Adjusted Net Sales and Value Added Framework: The Case of Japan [PDF]

open access: yes
This paper applies the nationality-adjusted net sales and value added framework proposed in Baldwin and Kimura (1996) to Japan. Despite possibly large estimation errors due to statistical deficiencies, the framework is very useful for analyzing the ...
Fukunari Kimura, Robert E. Baldwin
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

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