Results 161 to 170 of about 121,831 (194)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Dollo Parsimony Overestimates Ancestral Gene Content Reconstructions. [PDF]

Genome Biol Evol
Gàlvez-Morante A, Guéguen L, Natsidis P, Telford MJ, Richter DJ.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Determining the Role of Electrostatics in the Making and Breaking of the Caprin1-ATP Nanocondensate. [PDF]

J Phys Chem B
Tsanai M, Head-Gordon T.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Associations between snowboard coaches teaching interaction, motion guidance, and effectiveness assessment competencies and learners intentions to continue lessons. [PDF]

Front Psychol
Liu J, Hu T, Yin J.
europepmc   +1 more source

The sandfish identity: phylogeographic reconstructions uncover a species complex within the Indo-Pacific distribution of Holothuria (Metriatyla) scabra. [PDF]

BMC Ecol Evol
Brown KT, Southgate PC, Duy NDQ, Havimana L, Mmochi AJ, Basiita RK, Delghandi M, Stockwell B, Lal MM.   +8 more
europepmc   +1 more source

Subword Representations Successfully Decode Brain Responses to Morphologically Complex Written Words. [PDF]

Neurobiol Lang (Camb)
Hakala T, Lindh-Knuutila T, Hultén A, Lehtonen M, Salmelin R.   +4 more
europepmc   +1 more source

Still No Evidence for an Effect of the Proportion of Non-Native Speakers on Natural Language Complexity. [PDF]

Entropy (Basel)
Koplenig A.
europepmc   +1 more source

Phylogenetic Estimation of branch-specific Shifts in the Tempo of Origination

Kopperud BT, Höhna S.
europepmc   +1 more source