Results 181 to 190 of about 168,974 (306)

A Latent-factor MCACE Model for Multidimensional Outcomes and Treatment Noncompliance with Application to a Longitudinal Trial of Arthritis Health Journal. [PDF]

Stat Med
Guo L, Qian Y, Lacaille D, Xie H.
europepmc   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

A Review of R Packages for Bayesian Model-based Clustering of High-dimensional Multivariate Environmental Exposures. [PDF]

Curr Environ Health Rep
Stephenson BJK, Fu Y.
europepmc   +1 more source

The Estimation of Randomization Parameters in the Analysis of Multivariate Random Processes

Global Nuclear Safety, 2018
V.V. Krivin, V.A. Tolstov, I.O. Ishigov
openaire   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

A leakage-aware entropy screening protocol for structured biomarker panel evaluation in ovarian cancer risk modelling. [PDF]

MethodsX
P DLK, P M.
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

The impact of left ventricular assist devices on kidney function: a systematic review and meta-analysis. [PDF]

Egypt Heart J
Hosseini A, Darouei B, Amani-Beni R, Shafie D, Mazaheri-Tehrani S, Haghighatpanah MA, Heidarpour M, Amini-Salehi E, Hashemi SM, Harrison A, Hameed I, Reid CM, Movahed MR.   +12 more
europepmc   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Multivariate Regression With Dependence Structures: Evaluating Associations Between Plasma Metabolomics and Alcohol Intake in Older Adults. [PDF]

Stat Med
Yang Y, Chen C, Lee H, Wang M, Zhang Y, Chen S.   +5 more
europepmc   +1 more source