Results 151 to 160 of about 22,611 (308)
British Journal of Clinical Pharmacology, EarlyView.Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins +23 more
wiley +1 more source
Nonparametric Identification and Estimation in a Generalized Roy Model [PDF]
This paper considers nonparametric identification and estimation of a generalized Roy model that includes a non-pecuniary component of utility associated with each choice alternative.
Christopher Timmins +2 more
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British Journal of Clinical Pharmacology, EarlyView.Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen +8 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas +16 more
wiley +1 more source
Efficient Estimation for Dimension Reduction with Censored Survival Data
, 2022 Ge Zhao, Yanyuan Ma, Wenbin Lu
semanticscholar +1 more source
A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer
Cancer Nexus, EarlyView.ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley +1 more source
A spline-based nonparametric analysis for interval-censored bivariate survival data.
Statistica sinica, 2022 Yuan Wu, Ying Zhang, Junyi Zhou
semanticscholar +1 more source
Anifrolumab Dose Regimen Selection for a Phase 3 Trial in Lupus Nephritis
Clinical Pharmacology &Therapeutics, EarlyView.In patients with systemic lupus erythematosus (SLE), increased type I interferon signaling is associated with increased disease activity across organs, including in the kidney, which can cause lupus nephritis (LN). Anifrolumab, which abrogates type I interferon signaling, is an approved treatment for moderate to severe SLE.
Joachim Almquist +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries +8 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 832-838, April 2025.Abstract Aim Heart failure (HF) is a highly prevalent condition managed in both primary care (PC) and hospital care (HC)‐based settings. HF patients managed in these two settings may differ in their demography, comorbidities and outcomes, so we aimed to compare the patient management in PC and HC in the Västra Götaland Region (VGR) in Sweden.
Xiaojing Chen +4 more
wiley +1 more source