Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
Nature CommunicationsCheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood.
Sarah M. Merrill +19 more
doaj +1 more source
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
A comparison of minimum distance and maximum likelihood techniques for proportion estimation [PDF]
The estimation of mixing proportions P sub 1, P sub 2,...P sub m in the mixture density f(x) = the sum of the series P sub i F sub i(X) with i = 1 to M is often encountered in agricultural remote sensing problems in which case the p sub i's usually ...
Gray, H. L. +3 more
core +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Preliminary evaluation of ERTS-1 for determining numbers and distribution of prairie ponds and lakes [PDF]
ERTS-1 and aircraft multispectral data collected over a North Dakota test site during July 1972, are compared to evaluate the capability of the satellite sensors to detect numbers and distribution of prairie ponds and lakes. Recognition maps using ERTS-1,
Gilmer, D. S. +2 more
core +1 more source
Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund +3 more
wiley +1 more source
Multistatic radar distribution geometry effects on parameter estimation accuracy
IET Radar, Sonar & NavigationAn analysis of the parameter estimation uncertainty for the target location and velocity achievable using a single‐transmitter‐multiple‐receiver multistatic radar system is presented.
D. Dhulashia, M. A. Ritchie
doaj +1 more source
Evaluating the Use of Analyst Labels in Maximum Likelihood Cluster Proportion Estimation [PDF]
There are no author-identified significant results in this ...
Lennington, R. K., Terrell, G. R.
core +1 more source
Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew +11 more
wiley +1 more source
Alternative estimating and testing empirical strategies for fractional regression models [PDF]
In many economic settings, the variable of interest is often a fraction or a proportion, being defined only on the unit interval. The bounded nature of such variables and, in some cases, the possibility of nontrivial probability mass accumulating at one ...
Esmeralda A. Ramalho +2 more
core