Results 71 to 80 of about 1,365,805 (285)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Estimation of parameter of proportion in Binomial Distribution Using Adjusted Prior Distribution

open access: yesپژوهش‌های ریاضی, 2017
Historically, various methods were suggested for the estimation of Bernoulli and Binomial distributions parameter. One of the suggested methods is the Bayesian method, which is based on employing prior distribution.
h esfandiari   +3 more
doaj  

Optimal Allocation of the Sample in the Poisson Item Count Technique

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2018
Indirect methods of questioning are of utmost importance when dealing with sensitive questions. This paper refers to the new indirect method introduced by Tian et al.
Michał Bernardelli, Barbara Kowalczyk
doaj   +1 more source

From marine park to future genomic observatory? Enhancing marine biodiversity assessments using a biocode approach [PDF]

open access: yesBiodiversity Data Journal, 2019
Few tropical marine sites have been thoroughly characterised for their animal species, even though they constitute the largest proportion of multicellular diversity. A number of focused biodiversity sampling programmes have amassed immense collections to
Yin Cheong Aden Ip   +7 more
doaj   +3 more sources

Bayesian Joint Estimation of Binomial Proportions [PDF]

open access: yesJournal of Educational Statistics, 1991
Testing the hypothesis H that k > 1 binomial parameters are equal and jointly estimating these parameters are related problems. A Bayesian argument can simultaneously answer these inference questions: to test the hypothesis H, the posterior probability λ = λ (H | x) of H given the experimental data x can be used; to estimate each binomial parameter,
openaire   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Uniformly consistently estimating the proportion of false null hypotheses via Lebesgue-Stieltjes integral equations

open access: yes, 2019
The proportion of false null hypotheses is a very important quantity in statistical modelling and inference based on the two-component mixture model and its extensions, and in control and estimation of the false discovery rate and false non-discovery ...
Chen, Xiongzhi
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Segment-level evaluation of the simulated aggregation test: US corn and soybean exploratory experiment [PDF]

open access: yes
An evaluation of the corn and soybean proportion-estimation accuracy and dot labeling accuracy of the Simulated Aggregation Test, U.S. Corn and Soybean Exploratory Experiment, is presented.
Davidson, S. A.
core   +1 more source

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