Results 71 to 80 of about 202,812,532 (248)

Control procedures and estimators of the false discovery rate and their application in low-dimensional settings: an empirical investigation

BMC Bioinformatics, 2018
Background When many (up to millions) of statistical tests are conducted in discovery set analyses such as genome-wide association studies (GWAS), approaches controlling family-wise error rate (FWER) or false discovery rate (FDR) are required to reduce ...
Regina Brinster, Anna Köttgen, Bamidele O. Tayo, Martin Schumacher, Peggy Sekula, on behalf of the CKDGen Consortium   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Estimation of Proportion of a Finite Population [PDF]

, 2020
This paper discusses and presents maximum likelihood estimators of proportion for finite population as an alternative to the standard estimator. The properties of the obtained random sample under simple random sampling are investigated.
Yongyuth Chaiyapong
core  

Adaptive strategies in unrelated question randomized response techniques for sensitive data collection

Research in Statistics
When surveys involve sensitive issues-such as gambling habits, drug addiction, alcoholism, tax evasion, induced abortions, drunk driving, criminal history, or homosexuality non-response and response biases frequently occur, as respondents may be ...
Khalid Ul Islam Rather, Osama Abdulaziz Alamri, Tanveer Ahmad Tarry   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Precision of proportion estimation with binary compressed Raman spectrum

, 2017
International audienceThe precision of proportion estimation with binary filtering of a Raman spectrum mixture is analyzed when the number of binary filters is equal to the number of present species and when the measurements are corrupted with Poisson ...
de Aguiar, Hilton, B, Rigneault, Herve, Galland, Frédéric, Réfrégier, Philippe, Scotté, Camille, Philippe Réfrégier, Hilton B. de Aguiar, Hervé Rigneault, Camille Scotté, Frédéric Galland, de Aguiar, Hilton,   +10 more
core   +1 more source

Confidence Interval Estimation of Proportion Near Zero or One: A Modeling Secondary Study

مجله اپیدمیولوژی ایران, 2017
Background and Objectives: When computing a confidence interval for a binomial proportion p, one must choose an exact interval that has a coverage probability of at least 1-α for all values of p.
S Hamzeh, AR Soltanian, J Faradmal
doaj  

Analytic Formulae for Estimating Motor Proportion of Load Model Under Small Disturbance

CSEE Journal of Power and Energy Systems
In the composite load model (CLM), which is commonly used in China, an equivalent motor and equivalent static load are used to represent all electrical equipment and networks connected to a load bus.
Ping Ju, Shiqiu Xia, Yuqing Jin, Lu Cao
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source