Results 91 to 100 of about 168,400,762 (297)
The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers. [PDF]
Influenza Other Respir Viruses, 2022 Racine É +16 more
europepmc +2 more sources
Desirable Portfolios in Fixed Income Markets: Application to Credit Risk Premiums
Risks, 2018 An arbitrage portfolio provides a cash flow that can never be negative at zero cost. We define the weaker concept of a “desirable portfolio” delivering cash flows with negative risk at zero cost.
José Garrido, Ramin Okhrati
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Coping with catastrophic risk : the role of (non)-participating contracts
, 2002 This paper examines how the two fundamentals principles in risk allocation, i.e., the mutuality principle and the transfer principle, can be implemented in order to manage efficiently catastrophic risk.
European Group of Risk and Insurance Economists, . +1 more
core
The Web system for coronary disease risk estimation by logistic regression (“CHD risk”) [PDF]
Medicinski Glasnik, 2009 Aim Coronary and heart diseases (CHD) represent one of thegreatest medical problems in the developed world. To facilitatethe CHD probability estimation procedure, as well as to speed upthe procedure of making and issuing patient’s final diagnosis ...
Ines Drenjančević-Perić +2 more
doaj
Benefit-Cost Analysis of Security Systems for Multiple Protected Assets Based on Information Entropy
Entropy, 2012 This article proposes a quantitative risk assessment for security systems which have multiple protected assets and a risk-based benefit-cost analysis for decision makers.
Qing Cai +3 more
doaj +1 more source