Results 121 to 130 of about 994,443 (373)
ON THE ESTIMATION OF DISTANCE DISTRIBUTION FUNCTIONS FOR POINT PROCESSES AND RANDOM SETS
This paper discusses various estimators for the nearest neighbour distance distribution function D of a stationary point process and for the quadratic contact distribution function Hq of a stationary random closed set.
Dietrich Stoyan+3 more
doaj +1 more source
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria+3 more
wiley +1 more source
SolidPAC is an interactive battery-on-demand energy density estimator for solid-state batteries
Summary: Solid-state batteries hold the promise to be highly impactful next-generation technologies for high-energy and -power-density rechargeable battery applications.
Marm Dixit+6 more
doaj
Assessing Coupling Dynamics from an Ensemble of Time Series
Finding interdependency relations between time series provides valuable knowledge about the processes that generated the signals. Information theory sets a natural framework for important classes of statistical dependencies.
Germán Gómez-Herrero+5 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson+7 more
wiley +1 more source
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli+10 more
wiley +1 more source
Asymptotic Normality and Consistency of the Least Squares Estimators for Families of Linear Regressions [PDF]
Friedhelm Eicker
openalex +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen+2 more
wiley +1 more source
On Canonical Forms, Non-Negative Covariance Matrices and Best and Simple Least Squares Linear Estimators in Linear Models [PDF]
George Zyskind
openalex +1 more source