Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Video game use, lifestyle and its association with becoming overweight or obese in Mexican adolescents. [PDF]
Islas Mendoza Y +13 more
europepmc +1 more source
[Scientific training and RENACYT recognition in health science students]. [PDF]
Estrada-Araoz EG.
europepmc +1 more source
Quantifying urban and landfill methane emissions in the United States using TROPOMI satellite data. [PDF]
Wang X +10 more
europepmc +1 more source
Land expropriation, litigation, and reinterpretation of space in the genesis of the zoobotanical park of Museu Paraense Emílio Goeldi, 1895-1941. [PDF]
Leal D, Sanjad N.
europepmc +1 more source
Anaplastic lymphoma kinase-negative inflammatory myofibroblastic tumor of the appendix and ileocecal region: a rare clinical entity. [PDF]
Sánchez-Villegas MG +5 more
europepmc +1 more source
Co-design of a natural fiber-timber hybrid structural system using dual-robot coreless filament winding. [PDF]
Duque Estrada R +5 more
europepmc +1 more source

