Results 1 to 10 of about 322 (164)

Synthetic Progestins in Waste and Surface Waters: Concentrations, Impacts and Ecological Risk [PDF]

Toxics, 2022
Synthetic progestins (PGs) are a large family of hormones used in continuously growing amounts in human and animal contraception and medicinal therapies.
Maria João Rocha, Eduardo Rocha
doaj   +2 more sources

Progestins - a review of clinical application in gynecology [PDF]

Annals of Medicine
Aims Progestins are a group of substances with a wide range of applications. They are classified into pregnanes, estranes, and gonanes, and further divided into four generations based on their testosterone (TE) or progesterone (P4) origin.
Dominika Żyła, Dominika Kuźmiuk, Martyna Rynkowska, Małgorzata Satora, Krzysztof Kułak, Rafał Tarkowski   +5 more
doaj   +2 more sources

Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release [PDF]

Journal of Medicinal Chemistry
Thomas Koelblen, Christopher C Coss, Thomas P Burris   +2 more
exaly   +2 more sources

Identification of Biologically Diverse Tetrahydronaphthalen‐2‐ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol‐Inspired Compounds

ChemBioChem, Volume 24, Issue 5, March 1, 2023., 2023
Synthesis and profiling of a collection of compounds containing the A/B ring system of estradiol fused to nine secondary fragments uncovered five scaffolds with diverse phenotypes, including osteoblast differentiation and autophagy inhibition as well as modulators of tubulin polymerization and potassium channels.
Thomas Whitmarsh‐Everiss, Zhou Wang, Cecilie Hauberg Hansen, Laura Depta, Elisa Sassetti, Oliver Rafn Dan, Axel Pahl, Sonja Sievers, Luca Laraia   +8 more
wiley   +1 more source

New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community‐Based Solutions

Journal of Chemistry, Volume 2023, Issue 1, 2023., 2023
Across communities worldwide, various new psychoactive substances (NPSs) continue to emerge, which worsens the challenges to global mental health, drug rules, and public health risks, as well as combats their usage. Specifically, the vast number of NPSs that are currently available, coupled with the rate at which new ones emerge worldwide, increasingly
Chinaza Godswill Awuchi, Maduabuchi Patrick Aja, Nancy Bonareri Mitaki, Sonia Morya, Ikechukwu O. Amagwula, Chinelo Kate Echeta, Victory S. Igwe, Jorge F. Fernandez-Sanchez   +7 more
wiley   +1 more source

Restriction of Dietary Advanced Glycation End Products Induces a Differential Plasma Metabolome and Lipidome Profile

Molecular Nutrition &Food Research, Volume 65, Issue 23, December 2021., 2021
A diet with a low‐advanced glycation end product content induces specific metabolomics and lipidomic changes in plasma. These changes can be related to several pathways, related to lípid pathways involved in inflammation, and age‐related changes. Overall, they support diet‐induced enhancements in oxidative stress resilience.
Rebeca Berdún, Mariona Jové, Joaquim Sol, Weijing Cai, John C. He, Reyna Rodriguez‐Mortera, Meritxell Martin‐Garí, Reinald Pamplona, Jaime Uribarri, Manuel Portero‐Otin   +9 more
wiley   +1 more source

Annual banned‐substance review: Analytical approaches in human sports drug testing 2019/2020

Drug Testing and Analysis, Volume 13, Issue 1, Page 8-35, January 2021., 2021
Detection assays for drugs and methods of sports doping published between 2019 and 2020 are critically reviewed and evaluated in context with the Prohibited List 2020 as established by the World Anti‐Doping Agency. Abstract Analytical chemistry‐based research in sports drug testing has been a dynamic endeavor for several decades, with technology‐driven
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Seaweed functional diversity revisited: Confronting traditional groups with quantitative traits

Journal of Ecology, Volume 108, Issue 6, Page 2390-2405, November 2020., 2020
A comprehensive dataset of directly measured functional traits revealed extensive mismatch between commonly used ‘traditional’ seaweed functional groups and underlying traits. Traditional grouping schemes are practical and allow first order approximations, but risk considerable loss of functional information.
Alizée R. L. Mauffrey, Laura Cappelatti, John N. Griffin, Mahasweta Saha   +3 more
wiley   +1 more source

13C-NMR and mass spectral data of steroids with a 17,17-dialkyl-18-nor-13(14)-ene substructure

Journal of Lipid Research, 1997
We present carbon-13 nuclear magnetic resonance (13C-NMR) and mass spectral data for several androstanes and estranes having a 17,17-dialkyl-18-nor-13(14)-ene substructure. These compounds are formed by a Wagner-Meerwein rearrangement of steroids bearing
V I De Brabandere, L M Thienpont, D Stöckl, A P De Leenheer   +3 more
doaj   +1 more source

The 5 Alpha‐Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

Advances in Urology, Volume 2012, Issue 1, 2012., 2012
Despite the discovery of 5 alpha‐reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha‐reduced steroids in human diseases was not appreciated until the discovery of 5 alpha‐reductase type 2 deficiency in 1974. Affected males are born
Faris Azzouni, Alejandro Godoy, Yun Li, James Mohler, Colleen Nelson   +4 more
wiley   +1 more source