Results 211 to 220 of about 239,432 (343)

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

The effects of oral medroxyprogesterone acetate combined with conjugated equine estrogens on inflammation in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Endocrinol (Lausanne)
Qiu J, He Y, Li J, Safargar M, Prabahar K, Shi Q.   +5 more
europepmc   +1 more source

Simultaneous removal of estrogens and pathogens from secondary treated wastewater by solar photocatalytic treatment [PDF]

, 2014
Chatzisymeon, E., Fanourgiakis, S., Frontistis, Z., Mantzavinos, D., Venieri, D.   +4 more
core  

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Chapter 3. Impact of estrogens on hemostasis. [PDF]

Front Endocrinol (Lausanne)
Stanczyk FZ, Sriprasert I, Chulapongwanich S, Yang JL, Fruzzetti F.   +4 more
europepmc   +1 more source

Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat

, 2009
Jomo A. Claiborne, Subodh Nag, S.S. Mokha   +2 more
openalex   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Risk of Cognitive Decline in Women with Parkinson's Disease Is Reduced by Early Age at Menarche. [PDF]

Neurol Int
Schirò G, Fazio C, Aridon P, Gagliardo C, Davì C, Picciolo V, Colletti T, Tumminia C, Iacono S, Ragonese P, D'Amelio M.   +10 more
europepmc   +1 more source

Natural ovarian stimulation (NATOS): an innovative controlled ovarian hyperstimulation (COH) protocol that combines large oocyte availability and physiologic estrogenic environment [PDF]

, 2013
Elodie Adda-Herzog, Michaël Grynberg, Sergio Parco, S. Sebag-Peyrelevade, Marine Poulain, Rénato Fanchin   +5 more
openalex   +1 more source

Histopathological evaluation of abnormal uterine bleeding with immunohistochemical study of significant estrogen receptor expression in endometrium of women with different age groups

, 2023
Ankita Singh, Dipti Tripathi, Pratima Singh, Sanjay Agrawal   +3 more
openalex   +2 more sources