Results 211 to 220 of about 160,774 (316)

Functionalized in Triplicate: A Ring‐By‐Ring Approach to Tailored Prodiginine Derivatives for Site‐Specific Conjugation Through Click Chemistry

open access: yesChemistry – A European Journal, EarlyView.
Prodigiosin is a potent cytotoxic alkaloid but lacks target selectivity. We advance functionalization of all three pyrrole rings of prodigiosin to enable site‐specific conjugation via click chemistry. The presented azide‐ and maleimide‐functionalized prodiginines are suitable for generating covalent prodiginine conjugates and attaching auspicious ...
T. Moritz Weber, Jörg Pietruszka
wiley   +1 more source

Sex Bias in Systemic Sclerosis: from Clinical to Immunological Differences. [PDF]

open access: yesClin Rev Allergy Immunol
Sakkas LI, Bogdanos DP, Chikanza IC.
europepmc   +1 more source

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

open access: yesChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia   +4 more
wiley   +1 more source

Development of Carborane‐Based Halogenated Naphthyridinone‐Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands

open access: yesChemMedChem, EarlyView.
There is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Lea Ueberham   +4 more
wiley   +1 more source

Estrogen Mineralization by a Modular Plug Flow Photocatalytic Reactor. [PDF]

open access: yesACS Omega
Bobirică L   +3 more
europepmc   +1 more source

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