Results 251 to 260 of about 186,980 (339)

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

open access: yesAdvanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma   +18 more
wiley   +1 more source

Techno-Economic Analysis and Life Cycle Assessment of Alternative Fuels for Locomotives in the U.S. Freight Rail Sector. [PDF]

open access: yesEnviron Sci Technol
Huang TY   +6 more
europepmc   +1 more source

Visible Light-Driven Photoelectrochemical Conversion of the By-Products of the Ethanol Fuel Cell into Hydrogen

open access: bronze, 2009
Piotr J. Barczuk   +4 more
openalex   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen   +9 more
wiley   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

open access: yesAdvanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi   +10 more
wiley   +1 more source

Cool-Flame Behaviors of an n-Decane/Ethanol Binary-Fuel Droplet in Microgravity

open access: bronze, 2009
Osamu Moriue   +4 more
openalex   +2 more sources

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

open access: yesAdvanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen   +7 more
wiley   +1 more source

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