Results 291 to 300 of about 3,942,350 (366)
Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao+9 more
wiley +1 more source
Role of large language models in mental health research: an international survey of researchers' practices and perspectives. [PDF]
Linardon J+7 more
europepmc +1 more source
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen+9 more
wiley +1 more source
Corrigendum to "Secondary school teachers code of ethics in Ethiopia: Implications for policy and practice" [Heliyon Volume 8, Issue 10, October 2022, Article e10885]. [PDF]
Ayenalem KA+3 more
europepmc +1 more source
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang+14 more
wiley +1 more source
FOREIGN EXPERIENCE IN IMPLEMENTING ETHICAL CODES IN LAW ENFORCEMENT ACTIVITIES
С. І. Бугера
openalex +1 more source
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang+9 more
wiley +1 more source