Results 81 to 90 of about 3,942,350 (366)
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Perception of and attitude toward ethical issues among Korean occupational physicians
Annals of Occupational and Environmental Medicine, 2017 Background Occupational physicians (OPs) have complex relationships with employees, employers, and the general public. OPs may have simultaneous obligations towards third parties, which can lead to variable conflicts of interests.
Junghye Choi +11 more
doaj +1 more source
Resource Guide in Exploring Ethics: A Practical Resource Guide for Tutors and Students [PDF]
, 2009 This resource guide will help staff and students who are studying social sciences in hospitality, tourism, entertainment, events, leisure. It outlines the ethical issues that they need to consider when conducting research for their dissertation or for ...
Kenyon, AJ, Wood, E
core
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Clinical Pathways to Ethically Substantive Autonomy [PDF]
, 2013 There is no shortage of support for the idea that ethics should be incorporated into the academic and professional curriculum. There is a difference, however, between, on the one hand, teaching professionals about ethics, and, on the other, demanding ...
Drake, Philip, Toddington, Stuart
core +2 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Revision of the Code of Ethics. [PDF]
JAMA: The Journal of the American Medical Association, 1893 To the Editor of the Journal of the American Medical Association: Dear Sir: —While the question of the revision of the Code of Ethics is under discussion, and before the meeting of the Association in June, I should like, with your permission, to say a few words in relation to the proposition. Most of those who have written on this subject were, as we
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Human resources managers as custodians of the King III code
South African Journal of Economic and Management Sciences, 2015 The objective of this research was to perform an exploratory study on the knowledge and understanding of the King III code among Human Resources (HR) managers in South African companies.
Frank de Beer, Daniel Hercules du Toit
doaj +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source