Results 91 to 100 of about 205,537 (258)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Ethical practice in clinical and research settings

open access: yesArchives of Mental Health, 2014
Medicine and its practice have a responsibility not to cause harm. Ethical values lie at the heart of clinical practice. Ethical values are even more important in psychiatry –a medical discipline where its practitioners have been handed responsibility ...
Dinesh Bhugra   +2 more
doaj  

Selected Aspects of the Unfair Struggle for Job Positions

open access: yesActa Academiae Beregsasiensis. Economics
The topic of unfair competition for job positions is a significant yet underexplored issue within the domains of managerial and business ethics. This study aims to shed light on this problem by examining three core themes related to unethical struggles ...
Мarian Аmbrozy, Zuzana Kuběnová
doaj   +1 more source

Introducing ethical codes in public broadcasting services: Experience of Bosnia and Herzegovina, Montenegro, Croatia, Macedonia and Slovenia [PDF]

open access: yesCM. Communication and Media, 2017
Staring from the idea of self-regulation as the most optimal model of democratic and accountable regulation of the media sphere, especially in the field of electronic media, this paper provides a comparative analysis of norms and procedures pertaining to
Nikolić Mirjana
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Researcher's Role: An Ethical Dimension

open access: yesOutlines, 2006
Different paradigms or perspectives function as the point of departure and framework for research. In this article ethical issues in the positivist and constructivist paradigms are presented.
May Britt Postholm, Janne Madsen
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

INTERACCIONES INDUSTRIA & RADIOLOGIA: LOGROS INNEGABLES, CONFLICTOS DE INTERESES POSIBLES. LOS OBSEQUIOS DE LA INDUSTRIA

open access: yesRevista Chilena de Radiología, 2006
Los conflictos de intereses son muy frecuentes y diversos en medicina, tienen un gran impacto tanto en la información que llega a los profesionales de la salud como en la atención médica y, en su gran mayoría no son divulgados.
César García M   +2 more
doaj  

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