Results 171 to 180 of about 273,332 (281)

Cholesterol Metabolism Regulated Nanoliposome Ameliorates Chemo/Photothermal Therapy Reversing CD8+ T Cell Exhaustion

open access: yesExploration, EarlyView.
Our work addresses the challenge of treating triple‐negative breast cancer by developing a multifunctional nanoliposome, ictLipo. The goal was to enhance antitumor immunity by combining photothermal therapy and chemotherapy while simultaneously tackling two major roadblocks: immunosuppression from cholesterol in the tumor microenvironment and therapy ...
Panpan Xue   +5 more
wiley   +1 more source

Ethical dilemmas in continuing pregnancy after a prenatal diagnosis of congenital heart defects: a systematic review and narrative synthesis. [PDF]

open access: yesBMC Med Ethics
Kalhor F   +6 more
europepmc   +1 more source

One‐Stone‐Two‐Birds Carrier‐Free Nano‐Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment

open access: yesExploration, EarlyView.
ABSTRACT Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness characteristics in non‐stem cancer cells. Herein, we propose a cancer cells/CSCs double‐killing modality
Tongyao Zhao   +10 more
wiley   +1 more source

When Rare Is Not Small: Amyotrophic Lateral Sclerosis Initiatives and Therapy

open access: yesExploration, EarlyView.
In the precision‐medicine era, rare diseases must not be sidelined in translational infrastructure. The Mr. Cai Lei—led “Ice‐Breaking Team” turns an amyotrophic lateral sclerosis patient community into a sustainable ecosystem, realigning philanthropy, data, and research and development to reshape rare‐disease pipelines and guide precision therapies ...
Yang Liu   +6 more
wiley   +1 more source

Caught in the fire: An accidental ethnography of discomfort in researching sex work

open access: yesFeminist Anthropology, EarlyView.
Abstract Drawing on fifteen years of engagement with researching Israel's sex industry, this article uses accidental ethnography to propose discomfort‐as‐method for feminist anthropology. I argue that discomfort is not a by‐product of fieldwork but a constitutive condition that disciplines researchers and shapes what can be known.
Yeela Lahav‐Raz
wiley   +1 more source

Ethical Dilemmas in Pain Management for Frail and End-of-Life Elderly Patients: Balancing Relief, Autonomy, and Clinical Uncertainty. [PDF]

open access: yesCureus
Idahor CO   +8 more
europepmc   +1 more source

“I Need to Be Prepared”: EFL Teachers in Korea and GenAI's Influence on Their Professional Identities

open access: yesFuture in Educational Research, EarlyView.
ABSTRACT The proliferation of generative artificial intelligent (GenAI) models and tools are revolutionizing how existing practices are transformed across multiple industries, including English language education. Simultaneously, the capabilities of these models are shaping how teachers reevaluate their roles as educators, especially in high‐stakes ...
Josh Hayes, A. Jane Loper
wiley   +1 more source

DeepSeek in Education: Exploring the Transformative Potential of AI‐Driven Educational Intelligence

open access: yesFuture in Educational Research, EarlyView.
ABSTRACT The integration of artificial intelligence into education remains challenged by issues of scalability, interpretability, and multimodal adaptability. DeepSeek's AI‐driven educational tools show potential to improve educational applications through advances in reasoning efficiency, lightweight deployment, and multimodal fusion.
Jian Liao, Fan Sun, Yajie Liu, Yuli Hu
wiley   +1 more source

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