Results 121 to 130 of about 8,890,530 (360)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Ethical issues to think about when using AI in healthcare
, 2023 Vikas V. Pawar, Safia Farooqui
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Business Ethics in Transition Countries – Cluster Analysis of Behavior and Attitudes [PDF]
The aim of this article is to obtain a better understanding of people’s attitudes toward ethical issues. We explored four ethics issues: (1) attitude on ethical issues in general, (2) information manipulation, (3) environmental issues, and (4) law issues.
Marina Dabić +2 more
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Guest Editorial ... Ethical Issues in Community and Research Medicine [PDF]
, 1971 The following guest editorial by Saltonstall Professor of Population Ethics, Arthur J. Dyck, is reprinted from the New England Journal of Medicine. In it reference is made to an article, Ethics of a Cottage Industry in an Age of Community and Research ...
Dyck, Arthur J.
core +1 more source
Ethical Issues Regarding CRISPR Mediated Genome Editing.
Current Issues in Molecular Biology, 2018 CRISPR-Cas9 has emerged as a simple, precise and most rapid genome editing technology. With a number of promising applications ranging from agriculture and environment to clinical therapeutics, it is greatly transforming the field of molecular biology ...
Z. Shinwari, Faouzia Tanveer, A. Khalil
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Southern African Journal of HIV Medicine, 2003 No abstract available.
Elsebe Klinck
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Ethics in AIED: Who cares? [PDF]
, 2018 The field of AIED raises far-reaching ethical questions with important implications for students and educators. However, most AIED research, development and deployment has taken place in what is essentially a moral vacuum (for example, what happens if a ...
Bektik, Duygu +3 more
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