Results 121 to 130 of about 2,148,458 (311)
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Ethical Issues in Engineering Models: Personal Reflections [PDF]
I start this contribution with an overview of my personal involvement—as an Operations Research consultant—in several engineering case-studies that may raise ethical questions; these case studies employ simulation models.
Kleijnen, Jack P.C.
core +1 more source
Ethics in AIED: Who cares? [PDF]
, 2018 The field of AIED raises far-reaching ethical questions with important implications for students and educators. However, most AIED research, development and deployment has taken place in what is essentially a moral vacuum (for example, what happens if a ...
Bektik, Duygu +3 more
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Proceedings of the Conference on Globalization and Its Discontents [PDF]
Increasing globalization and free trade agreements have generated a number of controversies. One significant issue is the potential conflict between free trade and ethical standards.
Joshua Frank
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Origins, foundations and scope of agricultural ethics: A conceptual framework [PDF]
International Journal of Ethics and SocietyIntroduction: The ethical dimensions of agriculture need to be explored, distinguishing between ethics in agriculture and ethics of agriculture. Ethics in agriculture is traditionally based on abstract moral theory, formulated through logical reasoning ...
Ahmad Abedi Sarvestani
doaj
Research Ethics and Fieldwork at New Consumption Communities [PDF]
, 2005 It is hard to deny that marketing practice has changed considerably during recent years. This is reflected in its increased focus on customisation, coproduction and interactive marketing, much of which has been enabled by new information technologies ...
Bekin, C
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source