Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI SENSITIVITAS ETIKA ( STUDI PADA INSPEKTORAT PROVINSI JAWA TENGAH) [PDF]
, 2012 This research is aimed to analyze whether the effect on the organization’s ethical culture and ethical orientation does have an influence on orientation of the ethical sensitivity of auditors who worked on the Inspectorate of the Central Java Province.
KARTIKASARI, Pramita Diah, SYAFRUDIN, M
core
Sifat Machiavellian, Orientasi Etis, Equity Sensitiivity dan Budaya Jawa terhadap Perilaku Etis dengan Independensi sebagai Variabel Intervening [PDF]
, 2017 This study would like to examine the influences on Machiavellian characteristic, Equity Sensitivity, and Javanese Culture to Ethical Behavior as the intervening variable. Sample used inthis study was auditor at KAP in Surabaya.
Kartika, T. P. (Titis)
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
THE EFFECT OF ETHICAL SENSITIVITYOF SME’s OWNER ON THE CORPORATE SOCIAL RESPONSIBILITYINTENTIONS TO PROMOTE SME’s REPUTATION [PDF]
, 2017 Corporate social responsibility (CSR) has become interesting topic on the small and medium enterprises (SMEs). It is believed to be able to increase various advantages for SME’s.
Candra Sari, Ratna +2 more
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Ethical Competence for Teachers: A Possible Model [PDF]
, 2015 In Education Sciences, the notion of ‘competence’ is widely used, both as an aim to be reached with students and as performance in teachers’ education.
Ghiațău, Roxana-Maria
core +1 more source
Accountant's Ethical Sensitivity [PDF]
SSRN Electronic Journal, 2011 Anis Triki, Darlene Bay, Gail Lynn Cook
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Psychometric evaluation of the Persian version of the ethical sensitivity questionnaire for nursing students (ESQ-NS) [PDF]
PayeshObjective(s): Considering the complex and challenging work environment of nurses, it is necessary to study the ethical sensitivity of nursing students, for which there is no valid tool in Iran.
Reza Mohammadpour +3 more
doaj
Absolute and Relative Deprivation and the Measurement of Poverty [PDF]
This paper develops the link between poverty and inequality by focussing on a class of poverty indices (some of them well-known) which aggregate normative concerns for absolute and relative deprivation.
Duclos, Jean-Yves, Grégoire, Philippe
core +3 more sources