Results 71 to 80 of about 1,165,701 (302)

Ethical decision making [PDF]

, 2011
The self-centeredness of modern organizations leads to environmental destruction and human deprivation. The principle of responsibility developed by Hans Jonas requires caring for the beings affected by our decisions and actions.
Zsolnai, László
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Yoğun Bakım Hemşirelerinin Ahlaki Duyarlılık Düzeylerinin Yaşam Sonu Bakıma Yönelik Tutum ve Davranışlarına Etkisi: Tanımlayıcı ve Kesitsel Bir Çalışma

Yoğun Bakım Hemşireliği Dergisi
Amaç: Bu çalışma, yoğun bakımda çalışan hemşirelerinin ahlaki duyarlılık düzeylerinin yaşam sonu bakıma yönelik tutum ve davranışlarına etkisini belirlemek amacı ile yapıldı.
Suna Türkeköle, Gülendam Hakverdioğlu Yönt   +1 more
doaj   +1 more source

Students’ Research Ethics Competences and the University as a Learning Environment [PDF]

, 2014
The study focuses on the ethical sensitivity of university students in light of their research ethics skills and the university as a learning environment. Eighty-seven students in the behavioural sciences (psychology and educational science) responded to
Löfström, Erika, Rissanen, Minka
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Determining Intern Nurses Levels in Ethical Sensitivity and Empathy

Mediterranean Nursing and Midwifery
Objective: This descriptive study was designed to determine the ethical sensitivity and empathy levels of intern nurses. Method: The sample of this descriptive and cross-sectional study consisted of 100 fourth-year students enrolled in the nursing ...
Seda Cevheroğlu
doaj   +1 more source

SENSITIVITAS ETIS DAN PERTIMBANGAN ETIS MAHASISWA AKUNTANSI BERDASARKAN PENDIDIKAN ETIKA AKUNTANSI

Jurnal Akuntansi, 2019
This study examined the differences between ethical sensitivity and ethical judgement by students based on their knowledge of accounting ethics education.
Anggi Ayu Septi Kennedy, Lisa Martiah Nila Puspita   +1 more
doaj   +1 more source

Four Lenses for Designing Morally Engaging Games [PDF]

, 2016
Historically the focus of moral decision-making in games has been narrow, mostly confined to challenges of moral judgement (deciding right and wrong).
Formosa, Paul, Ryan, Malcolm, Staines, Dan   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

From Particularities to Context: Refining Our Thinking on Illness Narratives. [PDF]

, 2017
This paper examines how illness narratives are used in medical education and their implications for clinicians' thinking and care of patients. Ideally, collecting and reading illness narratives can enhance clinicians' sensitivity and contextual thinking.
Le, Annie, McMullin, Juliet, Miller, Kara   +2 more
core   +1 more source