Results 81 to 90 of about 26,406 (342)

Clinical Ethics Training in Canada: Moving Towards Standardization

Canadian Journal of Bioethics
This paper summarizes the presentation and stakeholder feedback gathered from the Canadian Bioethics Society Workshop and Community Forum in May 2023, in a session entitled, “Clinical Ethics Fellowship in Canada: Making the Move Towards Standardization”.
Winifred Badaiki, Andrea Frolic
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Empirical Data and Moral Theory. a Plea for Integrated Empirical Ethics

, 2004
Ethicists differ considerably in their reasons for using empirical data. This paper presents a brief overview of four traditional approaches to the use of empirical data: "the prescriptive applied ethicists," "the theorists," "the critical applied ...
Dupuis, Heleen M., Otten, Wilma, Molewijk, Bert, Stiggelbout, Anne M., Kievit, Job   +4 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Do Virtue Ethicists Parent Poorly?

Feminist Philosophy Quarterly
In this paper, I argue that virtue ethics is unfortunately committed to a developmentally detrimental form of moral evaluation in its traditional iterations.
J. B. Delston
doaj  

WELFARE, HEALTH, AND THE MORAL CONSIDERABILITY OF NONSENTIENT BIOLOGICAL ENTITIES

Les Ateliers de l’Ethique, 2018
This paper discusses a challenge to the claims made by biocentrists and some ecocentrists that some nonsentient biological entities (e.g., organisms, species, ecosystems) qualify as candidates for moral considerability.
Collège Lionel Groulx
doaj   +1 more source

The Theory and Practice of Virtue Education Edited by Tom Harrison and David I. Walker

Studia Gilsoniana, 2018
The collection of essays by different academics expresses a wide range of nuanced views on virtue ethics. Divided into three main parts, part one provides depth and breadth in introducing the history and philosophy of virtue education.
Brian Welter
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Ethical Issues Perceived by Clinical Ethicists [PDF]

, 2018
“Ethicists often work alone in rural locations while also holding leadership roles. Who helps the ethicist when he/she experiences an ethical dilemma or moral distress?” asked an ethicist.
Bosek, Marcia S, Brian Fulmer, Fulmer, Brian, Marcia S Bosek   +3 more
core   +1 more source