Results 21 to 30 of about 3,310,200 (292)

Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

BMC Medical Research Methodology, 2016
Background Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might be biased.
Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah, Sophia J. S. De Padua   +5 more
doaj   +1 more source

Clinical ethics committees

BMJ, 2000
Research ethics committees, both local and for multicentre research, are now well established in the United Kingdom. Clinical ethics committees, which deal with issues that arise in clinical practice, are a more recent phenomenon. Earlier this year people from 14 clinical ethics committees within the United Kingdom met to compare their experiences—at a
A M, Slowther, T, Hope
openaire   +3 more sources

Human neural stem cell transplantation in ALS: initial results from a phase I trial [PDF]

, 2015
We report the initial results from a phase I clinical trial for ALS. We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and ...
Bernardini, Laura, Bersano, Enrica, Binda, Elena, Boulis, Nicholas M, Cantello, Roberto, Carletti, Sandro, Carriero, Alessandro, Cerino, Annalisa, Cima, Valentina, Cisari, Carlo, Domenico, Frondizi, Ferrari, Daniela, Gaiani, Alessandra, Gelati, Maurizio, Giorgi, Cesare, Glass, Jonathan, Maglione, Annamaria, Masiero, Stefano, Massara, Maurilio, Mazzini, Letizia, Muzi, Gianmarco, Nasuelli, Nicola, Novelli, Antonio, Petruzzelli, Francesco, Prandi, Paolo, Profico, Daniela Celeste, Projetti Pensi, Massimo, Querin, Giorgia, Ricciolini, Claudia, Rota Nodari, Laura, Sarnelli, Maria Francesca, Servo, Serena, Sgaravizzi, Giada, Soraru', Gianni, Spera, Cristina, Stecco, Alessandro, Torres, Barbara, Trombetta, Domenico, Vescovi, Angelo L., Visioli, Alberto, Zalfa, Cristina   +40 more
core   +2 more sources

Prediction of life-story narrative for end-of-life surrogate’s decision-making is inadequate: a Q-methodology study

BMC Medical Ethics, 2019
Background Substituted judgment assumes adequate knowledge of patient’s mind-set. However, surrogates’ prediction of individual healthcare decisions is often inadequate and may be based on shared background rather than patient-specific knowledge.
Muhammad M. Hammami, Kafa Abuhdeeb, Muhammad B. Hammami, Sophia J. S. De Padua, Areej Al-Balkhi   +4 more
doaj   +1 more source

Targeted interventions for patellofemoral pain syndrome (TIPPS): classification of clinical subgroups [PDF]

, 2013
Introduction Patellofemoral pain (PFP) can cause significant pain leading to limitations in societal participation and physical activity. An international expert group has highlighted the need for a classification system to allow targeted intervention ...
Callaghan, M., Dey, Maria Paola, Dixon, J., Janssen, J., Martin, D., Richards, Jim, Ritchie, E., Selfe, James, Stokes, M., Sutton, Carley, Turner, D., Witvrouw, E.   +11 more
core   +3 more sources

Perceived Burdensomeness and the Wish for Hastened Death in Persons With Severe and Persistent Mental Illness

Frontiers in Psychiatry, 2021
Background: In several European countries, medical assistance in dying (MAID) is no longer confined to persons with a terminal prognosis but is also available to those suffering from persistent and unbearable mental illness.
Julia Stoll, Christopher James Ryan, Manuel Trachsel, Manuel Trachsel   +3 more
doaj   +1 more source

Verification, Analytical Validation, and Clinical Validation (V3): The Foundation of Determining Fit-for-Purpose for Biometric Monitoring Technologies (BioMeTs) [PDF]

, 2020
Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, ethics, patient advocacy, and healthcare policy, to name a few.
Bakker, Jessie, Bent, Brinnae, Coravos, Andrea, Dowling, Ariel, Fitzer-Attas, Cheryl, Godfrey, Alan, Godino, Job, Goldsack, Jennifer, Gujar, Ninad, Ismailova, Elena, Manta, Christine, Peterson, Barry, Vandendriessche, Benjamin, Wang, Ke, Wood, William   +14 more
core   +2 more sources

Clinical Ethics Committees in Africa: lost in the shadow of RECs/IRBs?

BMC Medical Ethics, 2020
Background Clinical Ethics Committees (CECs) are well established at healthcare institutions in resource-rich countries. However, there is limited information on established CECs in resource poor countries, especially in Africa.
Keymanthri Moodley, Siti Mukaumbya Kabanda, Leza Soldaat, Anita Kleinsmidt, Adetayo Emmanuel Obasa, Sharon Kling   +5 more
doaj   +1 more source

Multicentre observational cohort study of NSAIDs as risk factors for postoperative adverse events in gastrointestinal surgery [PDF]

, 2014
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as postoperative analgesia by the Enhanced Recovery After Surgery Society. Recent studies have raised concerns that NSAID administration following colorectal anastomosis may be ...
Bhangu, A, Chapman, SJ, Edward Fitzgerald, J, Glasbey, JCD, Kelly, M, Khatri, C, Nepogodiev, D   +6 more
core   +1 more source

Protocol for a systematic scoping review of reasons given to justify the performance of randomised controlled trials. [PDF]

, 2019
IntroductionRandomised controlled trials (RCTs) are widely viewed to generate the most reliable medical knowledge. However, RCTs are not always scientifically necessary and therefore not always ethical.
Chevrier, Stephanie, Dewar, Brian, Fedyk, Mark, Jurkovic, Lucas, Kitto, Simon C, Rodriguez, Rosendo, Saginur, Raphael, Shamy, Michel   +7 more
core   +2 more sources