Results 71 to 80 of about 3,310,200 (292)

Should Research Ethics Encourage the Production of Cost-Effective Interventions? [PDF]

, 2016
This project considers whether and how research ethics can contribute to the provision of cost-effective medical interventions. Clinical research ethics represents an underexplored context for the promotion of cost-effectiveness.
A Briggs, A Fleischman, A Rid, AD Paltiel, AJ London, AJ London, AM Garber, AS Kesselheim, C Grady, CC Denny, D Barnbaum, D Mortimer, D Wendler, DA Hyman, DB Resnik, DJ Torgerson, DM Dimichele, DR Buchanan, E Frank, ED Prentice, EE Roughead, EJ Emanuel, EJ Emanuel, EJ Emanuel, EJ Emanuel, EJ Emanuel, F Baylis, FA Lederle, G Yamey, GA Cohen, GR Wilensky, H Grabowski, HF Lynch, HG Frankfurt, HJ Curzer, I Rudan, J Cohen, J Dowie, J Harris, J McMahan, JA Tobert, JC Lindsey, JW Berg, L Bojke, LP Garrison Jr, M Angell, M Limb, MF Drummond, MJ Mehlman, MS Mano, N Daniels, NMP King, NMP King, PA Ubel, PJ Neumann, PJ Neumann, PR Orszag, PR Orszag, PT Menzel, PT Menzel, PT Menzel, R Dresser, RA Epstein, RA Rettig, RA Spinello, RK Lie, RL Fleurence, S Batt, S Joffe, S Palmer, S Thomson, S Woods, SE Weinberger, SK Shah, T Fojo, T Hurka, T Schrecker, TJ Zywicki, U Schüklenk, WC Black, Z Kmietowicz   +80 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Reinterpretation, reclassification, and its downstream effects: challenges for clinical laboratory geneticists

BMC Medical Genomics, 2019
Background In recent years, the amount of genomic data produced in clinical genetics services has increased significantly due to the advent of next-generation sequencing.
Julia El Mecky, Lennart Johansson, Mirjam Plantinga, Angela Fenwick, Anneke Lucassen, Trijnie Dijkhuizen, Annemieke van der Hout, Kate Lyle, Irene van Langen   +8 more
doaj   +1 more source

Pattern of antibiotic resistant mastitis in dairy cows [PDF]

Veterinary World, 2014
Aim: To study the prevalence of drug resistant mastitis and their pattern of antibiotic resistance in dairy cows from Tamil Nadu. Materials and Methods: Isolation and identification of resistant pathogens were performed from acute clinical mastitis ...
D. Chandrasekaran, P. Venkatesan, K. G. Tirumurugaan, A. P. Nambi, P. S. Thirunavukkarasu, K. Kumanan, S. Vairamuthu, S. Ramesh   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

EVALUATION OF LEFT ATRIUM AND AORTA IN TWO-DIMENSIONAL AND M-MODE ECHOCARDIOGRAPHY IN FEMALE MALABARI GOATS [PDF]

Journal of Veterinary and Animal Sciences, 2018
Left atrial to aortic ratio was evaluated using two-dimensional and M-mode echocardiography in twelve healthy adult female Malabari goats. The normal values of left atrium to aortic ratio in healthyMalabari goats in both the techniques varied ...
K.G. Tejaswini, N. MadhavanUnny, Usha Narayana Pillai, S. Ajithkumar, Thirupathy Venkatachalapathy   +4 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Caregivers and Family Members’ Vulnerability in End-of-Life Decision-Making: An Assessment of How Vulnerability Shapes Clinical Choices and the Contribution of Clinical Ethics Consultation

Philosophies
Patient-and-family-centered care (PFCC) is critical in end-of-life (EOL) settings. PFCC serves to develop and implement patient care plans within the context of unique family situations.
Federico Nicoli, Alessandra Agnese Grossi, Mario Picozzi   +2 more
doaj   +1 more source

An in-depth analysis of ethics teaching in Canadian Physiotherapy and Occupational Therapy programs [PDF]

, 2015
Purpose: The purpose of this study was to examine current approaches and challenges to teaching ethics in entry-level Canadian physiotherapy (PT) and occupational therapy (OT) programs.
Ehrmann Feldman, Debbie, Hudon, Anne, Hunt, Matthew, Laliberté, Maude, Mazer, Barbara, Williams-Jones, Bryn   +5 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source