Results 31 to 40 of about 3,141,195 (309)
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
The Role of Compassion in Medical Ethics and Its Reintegration in Modern Practice [PDF]
, 2019 Compassion has been an integral part of medical ethics since its origins, but as medicine progressed, compassion slowly disappeared from practice.
Borchers, Hannah E
core +1 more source
Demographics, Ethics, Awareness [PDF]
, 2010 Ethics in medicine is not a new concern. But it has become much more pronounced in modern times. The issues involved may range from right diagnosis and right treatment to the fees charged to patients, and the administration of insurance and medical bills.
Joshi, Himanshu +3 more
core +1 more source
American Journal of Islam and Society, 1996 It was indeed an auspicious occasion when experts in different academic fields came together to discuss questions confronting Muslim society based on recent medical advancements.
Khurshid Ahmad Nadeem
doaj +1 more source
Zhongguo gonggong weisheng, 2023 With the rapid and in-depth development of medical practice and medical research, medical ethics issues are receiving more and more attention; at the same time, population-related health surveys are also facing more and more medical ethics issues. How to
Hui-nan HAN, Xiao-yu WANG, Li-ping HAN
doaj +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source