Results 71 to 80 of about 2,246,211 (258)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A licitude civil da prática da ortotanásia por médico em respeito à vontade livre do paciente

open access: yesRevista Bioética
Por meio de interpretação constitucional baseada no princípio fundamental da dignidade da pessoa humana e no direito à vida, entende-se que a Constituição Federal protege o direito à morte digna, enquanto inexiste norma federal que disponha sobre o tema.
Maria Luiza Monteiro da Cruz   +1 more
doaj  

A Study of the Components of Medical Ethics in Ancient Persian Literature and Its Comparison with Modern Medical Ethics [PDF]

open access: yesArmaghane Danesh Bimonthly Journal
Background & aim: Findings from ancient Persian literary texts indicate that the issue of professional medical ethics and the correct and logical relationship between a doctor and a patient has not been hidden from the eyes of writers and poets.
A Ebrahimi Mehr
doaj  

What is a good health check? An interview study of health check providers’ views and practices

open access: yesBMC Medical Ethics, 2017
Background Health checks identify (risk factors for) disease in people without symptoms. They may be offered by the government through population screenings and by other providers to individual users as ‘personal health checks’.
Yrrah H. Stol   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Discussão Ética sobre o Prontuário Eletrônico do Paciente

open access: yesRevista Brasileira de Educação Médica
RESUMO O prontuário do paciente constitui uma ferramenta fundamental para a prestação do cuidado em saúde, podendo ser definido como um registro padronizado e organizado de toda a informação referente à saúde de um indivíduo, desde o nascimento até a ...
Maria José Guedes Gondim Almeida   +3 more
doaj   +1 more source

Development of Strategies for Advancement of Medical Ethics Education in Isfahan University of Medical Sciences [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2013
Introduction: Medical ethics is an analytical attempt that deals with various aspects of ethical decision making in medicine. According to the importance and goals of medical ethics, this study is an endeavor to evaluate strengths and weaknesses ...
Parisa Malekahmadi, Parinaz parsa
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy