Results 121 to 130 of about 413,705 (266)

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source

Moral Distress in Ethical Dilemmas: A Comparative Study of Medical Students and Physicians. [PDF]

Healthcare (Basel)
Constantin GD, Hoinoiu B, Veja I, Mazilescu CA, Hoinoiu T, Luca RE, Munteanu IR, Oancea R.   +7 more
europepmc   +1 more source

The Adaptive Physical Activity Study in Stroke (TAPAS): A Feasibility Sequential Multiple Assignment Randomized Trial

Advanced Science, EarlyView.
This study examines the feasibility of a mobile health physical activity intervention for individuals post‐stroke using a sequential multiple assignment randomized trial (SMART) design. High recruitment, retention, and adherence rates are observed, with promising trends in step count, fatigue, and quality of life.
Aoife Whiston, Emma Carr, Nathan Cardy, Padraic Rocliffe, Siobhan M. O'Reilly, Daniel Carter, Mairead O'Donoghue, Aine Cronin, James G. Bradley, Mike Butler, Liam Glynn, Jane C. Walsh, Cathal Walsh, Kelley Kidwell, Margaret O'Connor, Chris Macey, Lorna Paul, Claire Fitzsimons, Julie Bernhardt, Jon Salsberg, Sara Hayes   +20 more
wiley   +1 more source

Understanding Employees' Attitudes and Awareness of Code of Ethics and Associated Factors: A Cross-Sectional Survey at a Public Tertiary Hospital in Croatia. [PDF]

Healthcare (Basel)
Hrgović Z, Krstulović J, Tavra A, Krešo A, Batinović F, Znaor L, Marušić A.   +6 more
europepmc   +1 more source

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

Advanced Science, EarlyView.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang, Hongyuan Zhu, Zeen Zhu, Shuai Wu, Yiqun Song, Jin Wang, Xinlong Chen, Weikun Qian, Jianpeng Li, Yangyang Yue, Qinhong Xu, Zhiping Ruan, Qing Li, Yaomin Zhu, Tian Jian Lu, Guy M. Genin, Feng Xu, Zheng Wang, Min Lin   +18 more
wiley   +1 more source

Exploring the new characteristics of professionalism in nursing from the perspective of experts: A qualitative Study. [PDF]

J Taibah Univ Med Sci
Parastesh S, Hosseini M, Mohammadi-Shahbolaghi F, Maddah SSB, Ebadi A.   +4 more
europepmc   +1 more source

MARCO+ Tumor‐Associated Macrophages Impede CD8+ T Cell Immunity to Facilitate Immunotherapy Resistance in Renal Cell Carcinoma

Advanced Science, EarlyView.
MARCO+ TAMs dominate restrained cytotoxicity of CD8+ CTLs and ICB resistance in RCC. Mechanically, MARCO impairs MHC‐I‐mediated neoantigen cross‐presentation via the SOCS1‐JAK1‐STAT1‐NLRC5 signaling cascade in TAMs. Targeted MARCO treatment boosts macrophage antigen cross‐presentation and empowers CD8+ T cells, thereby potentiating ICB efficacy ...
Jiayuan Chen, Jiazhi Mo, Jinchang Wei, Mengnan Qu, Jie Dai, Yan Kong, Huayan Xu, Juan Li, Xieqiao Yan, Chuanliang Cui, Lu Si, Zhihong Chi, Jun Guo, Xiaowen Wu, Xinan Sheng   +14 more
wiley   +1 more source

Ethical transgressions among healthcare professionals in South Africa from 2014 to 2023. [PDF]

Health SA
Pontarelli MA, Gezu Y, Nortjé M, Truong G, Ravi N, Baldassarre A, Hoffmann W, Nortjé N.   +7 more
europepmc   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source

Dental students' perceptions, attitudes, and professional approaches toward the use of social media in learning endodontics: a cross-sectional survey. [PDF]

BMC Med Educ
Gökyar M, Yıldırım G, Sazak Öveçoğlu H.   +2 more
europepmc   +1 more source