Results 121 to 130 of about 1,487,804 (301)
Advanced Science, EarlyView.This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang +17 more
wiley +1 more source
Ethics and Journalism in the Professional Culture of the Journalist of the Digital Age [PDF]
, 2017 Ethics is an immanent feature of the journalist’s professional culture and, in a narrower sense, professional ethics. In the digital age the activity of a journalist is based on the phenomenon of journalism. Codified journalistic morality came in contact
Ismailov, A. Yu +1 more
core
Advanced Science, EarlyView.We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang +8 more
wiley +1 more source
The Attitudes of Librarians in Hamadan Public Libraries Regarding the Professional Ethics [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2014 Purpose: The aim of this study is to examine the level of familiarity with professional ethics demonstrated by librarians in Hamadan public libraries, and to determine the factors affecting these librarians' attitudes towards professional ethics and ...
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doaj
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models
Advanced Science, EarlyView.His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li +13 more
wiley +1 more source
Professional ethics of intermediaries on the real estate market [PDF]
, 2012 Professional ethics may reduce transaction costs and improve relations between intermediaries and customers. In this article, a general overview of the basic principles of professional ethics of real estate intermediaries in Poland is ...
Piasecka, Aleksandra
core
Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy
Advanced Science, EarlyView.A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang +8 more
wiley +1 more source