Results 121 to 130 of about 3,457,063 (304)

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

open access: yesAdvanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen   +5 more
wiley   +1 more source

Smith & Brown: A case study for use in teaching in Engineering Ethics [PDF]

open access: yes, 2010
This is an Engineering Ethics case study from the IDEA CETL. It examines issues around the intellectual property of a joint project and subsequent research. The case study is aimed at students who have not studied ethics before.
Professor Ian Howard   +2 more
core  

Rediscovering the Virtues in Popular Film

open access: yesFilm-Philosophy, 2001
Adam Muller
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

open access: yesAdvanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu   +4 more
wiley   +1 more source

Proposed Professional Ethics Division definitions and rulings;Proposed Interpretation providing definitions of words and phrases as used in the AICPA Code of Professional Conduct;Proposed ethics ruling under rule 101: Member on advisory board of client;Proposed deletion of ethics rulings no. 147 and no. 148 under rule 505: Firm designation; Exposure draft (American Institute of Certified Public Accountants), 1989, May 1 [PDF]

open access: yes, 1989
The Professional Ethics Executive Committee proposes an interpretation of the Code of Professional Conduct that provides definitions of certain terms used in the Code. The defined terms determine the applicability of Code rules to the various segments of
American Institute of Certified Public Accountants. Professional Ethics Executive Committee
core  

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

open access: yesAdvanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu   +12 more
wiley   +1 more source

Disquiet on the research front : surveying the battle ground between researchers and human research ethics committees

open access: yes, 2004
In this paper, I play with the metaphors of war and peace (with apologies to Leo Tolstoy) as a strategy for describing the relations between (some) social science researchers and human research ethics committees.
Halse, Christine
core  

Ethics of professional courtesy [PDF]

open access: yesJournal of Vascular Surgery, 2004
Jones, James W   +2 more
openaire   +2 more sources

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

open access: yesAdvanced Science, EarlyView.
This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg   +19 more
wiley   +1 more source

Ethics Commission extends financial disclosure filing deadline

open access: yes, 2020
"March 27, 2020."; At head of title: For immediate release; "For more information, contact Paul M. Nick, Executive Director.
Ohio Ethics Commission
core  

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