Results 121 to 130 of about 3,549,935 (252)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Unveiling the Interfacial Dynamics of Crosslinked Biodegradable Polycaprolactone Solid Polymer Electrolytes and Li Metal During Lithium Plating and Stripping via Operando ATR‐FTIR Spectroscopy

Advanced Science, EarlyView.
This study presents a comprehensive interfacial characterization of the biodegradable PCL solid‐polymer electrolytes (SPEs) with Li metal, utilizing an advanced operando ATR‐FTIR spectroscopy. The investigation elucidates the interphase properties during Li plating/stripping in a zero‐excess cell configuration.
Jian‐Fen Wang, Matthias Weiling, Felix Pfeiffer, Marian C. Stan, Martin Winter, Masoud Baghernejad   +5 more
wiley   +1 more source

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

Advanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu, Huixuan Xu, Li Lin, Fei Wang, Yaodong Ding, Shuangqiao Liao, Xingyu Chen, Jichen Wen, Hongqiang Zhao, Jing Hao, Weixiang Zhao, Gong Zhang, Shiguang Shan, Yong Zeng, Hu Han, Minxian Wang   +15 more
wiley   +1 more source

Integrating ethics into pharmacy practice

, 2010
Current competency standards for pharmacists include 'Practise pharmacy in a professional and ethical manner'. In pharmacy programs, the prevailing method of teaching ethics is with problem-based learning involving dispensing and counselling practicals ...
King, Michelle, Hattingh, Laetitia
core  

Rediscovering the Virtues in Popular Film

Film-Philosophy, 2001
Adam Muller
doaj   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Organizational determinants of professional ethics among healthcare workers: implications for health system performance

BMC Health Services Research
Background Professional ethics is a critical component of healthcare workforce performance and plays an essential role in patient safety, service quality, and organizational accountability.
Khalil Maleki Chollou, Towhid Babazadeh, Amir Hossien Rostami, Saba Arabnezhad, Fatemeh Mousavinezhad, Erfan Saeedi Tazekand   +5 more
doaj   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Rethinking 'business is business' : a criticalist perspective on teaching business ethics

, 2005
This paper reports on a study into student perceptions of a Socratic approach to teaching business ethics. The paper lays out a criticalist proposition that there is a discourse of ‘ethics-in-business’ in which ethics are, pragmatically, subsumed by a ...
Fallon, Wayne
core