Results 151 to 160 of about 6,000,705 (381)

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

Ethics and the medical practitioner [PDF]

open access: yes, 1997
Historically, the inculcation of good ethical practice within the Maltese medical community has been achieved through a high ethical standard assumed by the teachers which was passed on to their students.
Cauchi, Maurice N.
core  

The Ethics of Immigration

open access: yesPolitical Studies Review, 2005
This review essay examines recent work in political theory on the ethics of immigration admissions. It considers arguments put forward by Michael Walzer, Peter Meilaender and David Miller, among others, for state control of borders. Such arguments tend to appeal to the value of political communities and/or the exclusion rights of democratic ...
openaire   +4 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

The Concept of Integrity and Its Application to Engineering Ethics [PDF]

open access: yes, 2014
Integrity is a common and well established concept in the ethical vocabulary. It is also being used in various codes of ethics, and investigated by means of various methods.
Wajszczyk, Piotr
core  

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Feminist Ethics [PDF]

open access: yes, 2017
This chapter begins by discussing what feminist ethics is and does through examination of a specific example of the spheres into which our lives are separated: the public and the private.
Miller, Sarah
core  

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