Results 41 to 50 of about 3,912,951 (289)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Patient concerns about AI-based voice analysis in healthcare

BMC Digital Health
Background Although AI-based voice analysis technology has potential utility for disease screening, diagnosis, clinical documentation, and safety monitoring, few studies have examined concerns that patients may have about the use of voice data for ...
J. E. Pacyna, M. D. Anzabi, A. M. Stroud, J. L. Wise, R. R. Sharp   +4 more
doaj   +1 more source

Is ETHICS about ethics? Evaluating the ETHICS benchmark

CoRR
ETHICS is probably the most-cited dataset for testing the ethical capabilities of language models. Drawing on moral theory, psychology, and prompt evaluation, we interrogate the validity of the ETHICS benchmark. Adding to prior work, our findings suggest that having a clear understanding of ethics and how it relates to empirical phenomena is key to the
Leif Hancox-Li, Borhane Blili-Hamelin
openaire   +2 more sources

Ethics Commission extends financial disclosure filing deadline

, 2020
"March 27, 2020."; At head of title: For immediate release; "For more information, contact Paul M. Nick, Executive Director.
Ohio Ethics Commission
core  

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Ethics support for ethics support: the development of the Confidentiality Compass for dealing with moral challenges concerning (breaching) confidentiality in moral case deliberation

BMC Medical Ethics
Background Confidentiality is one of the central preconditions for clinical ethics support (CES). CES cases which generate moral questions for CES staff concerning (breaching) confidentiality of what has been discussed during CES can cause moral ...
Wieke Ligtenberg, Margreet Stolper, Bert Molewijk   +2 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Ethical ethics committees?: a response [PDF]

Journal of Medical Ethics, 2000
sir Following Dr Barber's letter1 relating to the mechanism for approval of Local Research Ethics Committees (LRECs), I have also had concerns over the intense pressure for a fast turn around for local approval. Projects may have been six months or more in the Multicentre Research Ethics Committe (MREC) process and then arrive on my desk with ...
openaire   +2 more sources

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Implementing advance care planning in nursing homes – study protocol of a cluster-randomized clinical trial

BMC Geriatrics, 2018
Background Close to half of all deaths in Norway occur in nursing homes, which signals a need for good communication on end-of-life care. Advance care planning (ACP) is one means to that end, but in Norwegian nursing homes, ACP is not common.
Trygve Johannes Lereim Sævareid, Lillian Lillemoen, Lisbeth Thoresen, Reidun Førde, Elisabeth Gjerberg, Reidar Pedersen   +5 more
doaj   +1 more source