Results 171 to 180 of about 505,131 (352)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

International Perspectives of Ethical Approval:

Grounded Theory Review: An International Journal, 2010
The paper "Navigating the process of ethical approval" (Carey, 2010) raises many issues about the influence Institutional Ethics Committees have on research methodology and what can or cannot take place in research.
Antoinette M. McCallin
doaj  

Professional and academic profile of the Brazilian research ethics committees. [PDF]

BMC Med Ethics, 2022
de Veras Santos EP, Guerriero ICZ.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Ethics committees: Aspirations and responsibilities

Perspectives in Clinical Research, 2013
V S Padbidri, N Y Mahaparale
doaj   +1 more source

Evaluation of the first standardized registry of approved research studies by the research ethics committees in Ecuador. [PDF]

BMC Med Ethics
Simbaña-Rivera K, Jaramillo-Aguilar DS, Arteaga VHA, Estupiñán JR.   +3 more
europepmc   +1 more source

The role of nursing members in research ethics committees in Japan. [PDF]

Nagoya J Med Sci, 2022
Sakaida Y, Ota K, Sone C.
europepmc   +1 more source

A Standard Operating Procedures (SOPs) Manual Developed for Institutional Research Ethics Review Committee (IRERC) Wollo University, Ethiopia: Ubuntu Philosophy Integrated Framework for Multi-Disciplinary Research Ethics Review (WU-IRERC-SOPs-001-Version 2, Revised)

Andualem Yimer Desalegn
openalex   +1 more source

Is Your Ethics Committee Efficient? Using “IRB Metrics” as a Self-Assessment Tool for Continuous Improvement at the Faculty of Tropical Medicine, Mahidol University, Thailand

, 2014
Pornpimon Adams, Jaranit Kaewkungwal, Chanthima Limphattharacharoen, Sukanya Prakobtham, Krisana Pengsaa, Srisin Khusmith   +5 more
openalex   +2 more sources