NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
The role of research ethics committees in addressing optimism in sample size calculations: a meta-epidemiological study. [PDF]
Jansen MS, Groenwold RHH, Dekkers OM.
europepmc +1 more source
Are screening practice ethics committees needed? [PDF]
Wald N.
europepmc +1 more source
Correction to: Implementing clinical ethics committees as a complex intervention: presentation of a feasibility study in community care [PDF]
Morten Magelssen +3 more
openalex +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
To Explant or not to Explant Neural Implants: an Empirical Study into Deliberations of Dutch Research Ethics Committees. [PDF]
Bassil K, Jongsma K.
europepmc +1 more source
Multicentre research ethics committees [PDF]
John Alexander, Jeremy Whelan
openalex +1 more source
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini +7 more
wiley +1 more source
Correction to: Knowledge and Perceptions of Members and Staff of Ethics Committees and Investigators in China toward Conflicts of Interest in Clinical Research. [PDF]
Liu D, Zhou J.
europepmc +1 more source

