Results 31 to 40 of about 505,131 (352)

Prevalence, characteristics, and publication of discontinued randomized trials. [PDF]

, 2014
IMPORTANCE: The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear.
Akl, E.A., Amstutz, A., Bassler, D., Bengough, T., Blümle, A., Briel, M., Bucher, H.C., Burnand, B., Busse, J.W., Carrasco-Labra, A., Ebrahim, S., Faulhaber, M., Ferreira-González, I., Gloy, V., Guyatt, G.H., Hemkens, L.G., Johnston, B.C., Kasenda, B., Lamontagne, F., Meerpohl, J.J., Mertz, D., Moja, L., Mulla, S.M., Neumann, I., Nordmann, A., Raatz, H., Rosenthal, R., Saccilotto, R., Schandelmaier, S., Schwenkglenks, M., Stegert, M., Tikkinen, K.A., Tomonaga, Y., Vandvik, P.O., von Elm, E., Walter, M.A., Xin, S., You, J.   +37 more
core   +3 more sources

Human neural stem cell transplantation in ALS: initial results from a phase I trial [PDF]

, 2015
We report the initial results from a phase I clinical trial for ALS. We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and ...
Bernardini, Laura, Bersano, Enrica, Binda, Elena, Boulis, Nicholas M, Cantello, Roberto, Carletti, Sandro, Carriero, Alessandro, Cerino, Annalisa, Cima, Valentina, Cisari, Carlo, Domenico, Frondizi, Ferrari, Daniela, Gaiani, Alessandra, Gelati, Maurizio, Giorgi, Cesare, Glass, Jonathan, Maglione, Annamaria, Masiero, Stefano, Massara, Maurilio, Mazzini, Letizia, Muzi, Gianmarco, Nasuelli, Nicola, Novelli, Antonio, Petruzzelli, Francesco, Prandi, Paolo, Profico, Daniela Celeste, Projetti Pensi, Massimo, Querin, Giorgia, Ricciolini, Claudia, Rota Nodari, Laura, Sarnelli, Maria Francesca, Servo, Serena, Sgaravizzi, Giada, Soraru', Gianni, Spera, Cristina, Stecco, Alessandro, Torres, Barbara, Trombetta, Domenico, Vescovi, Angelo L., Visioli, Alberto, Zalfa, Cristina   +40 more
core   +2 more sources

Clinical ethics committees

BMJ, 2000
Research ethics committees, both local and for multicentre research, are now well established in the United Kingdom. Clinical ethics committees, which deal with issues that arise in clinical practice, are a more recent phenomenon. Earlier this year people from 14 clinical ethics committees within the United Kingdom met to compare their experiences—at a
A M, Slowther, T, Hope
openaire   +3 more sources

Rethinking research ethics committees in low- and medium-income countries

Research Ethics Review, 2018
Key historical landmark research malpractice scandals that shocked the international community (Nazi doctors’ experiments, Tuskegee study, Jewish chronic disease experiments, Krugman’s Willowbrook hepatitis study) were the origin of the institution of ...
Luchuo Engelbert Bain, Ikenna Desmond Ebuenyi, Nkoke Clovis Ekukwe, Paschal Kum Awah   +3 more
doaj   +1 more source

Ethics preparedness: facilitating ethics review during outbreaks - recommendations from an expert panel

BMC Medical Ethics, 2019
Background Ensuring that countries have adequate research capacities is essential for an effective and efficient response to infectious disease outbreaks.
Abha Saxena, Peter Horby, John Amuasi, Nic Aagaard, Johannes Köhler, Ehsan Shamsi Gooshki, Emmanuelle Denis, Andreas A. Reis, the ALERRT-WHO Workshop, Raffaella Ravinetto   +9 more
doaj   +1 more source

Redundant trials can be prevented, if the EU clinical trial regulation is applied duly

BMC Medical Ethics, 2020
The problem of wasteful clinical trials has been debated relentlessly in the medical community. To a significant extent, it is attributed to redundant trials – studies that are carried out to address questions, which can be answered satisfactorily on the
Daria Kim, Joerg Hasford
doaj   +1 more source

A 'good' ethical review: audit and professionalism in research ethics [PDF]

, 2015
How does one conduct, measure and record a ‘good’ ethical review of biomedical research? To what extent do ethics committees invoke professionalism in researchers and in themselves, and to what extent do they see competence as adherence to a set of ...
Brown, Campbell, Collier, Cruess, Douglas, Douglas-Jones, EMA (European Medicines Agency), Espeland, Foucault, Hedgecoe, Holden, International Conference on Harmonisation, Irwin, Jacob, Jensen, Karbwang-Laothavorn, Katz, Katz, Keck, Kipnis, Kleinman, Laidlaw, Lambek, Merry, Pels, Pels, Petryna, Power, Power, Reverby, Sariola, Shore, Stark, Stark, Strathern, Strathern, Sullivan, Taylor, Torres, Wilson, Wilson   +40 more
core   +1 more source

Research Ethics Committees [PDF]

British Journal of General Practice, 2008
Trials and Tribulations by Saul Miller1 takes the National Research Ethics Service to task for the closure of the Northumberland Research Ethics Committee (REC), but there are compelling reasons behind this decision. The Northumberland closure is part …
openaire   +2 more sources

Measuring inconsistency in research ethics committee review [PDF]

, 2017
Background The review of human participant research by Research Ethics Committees (RECs) or Institutional Review Boards (IRBs) is a complex multi-faceted process that cannot be reduced to an algorithm. However, this does not give RECs/ IRBs permission to
Kolstoe, Simon Erik, Trace, Samantha
core   +1 more source

Access to Ethics Committees in Bulgaria – Possibility or Probability

Acta Medica Bulgarica, 2019
The study of the legal framework regulating the activities of the Ethics Committees in the Member States of the European Union outlines several key factors forming the basis of the activity of the Ethics Committees. Compliance with the ethical principles
Gradinarova N.
doaj   +1 more source