Results 51 to 60 of about 574,820 (293)
Research governance in children's services: the scope for new advice (Research report DFE-RR072) [PDF]
, 2010 "In 2009, following a period of informal consultation with key stakeholders, the former DCSF commissioned the work reported here, with the following overarching aims: to identify and evaluate existing arrangements for research governance and ethics ...
Boddy, Janet, Oliver, Christine
core
The "unknown territory" of goal-setting: Negotiating a novel interactional activity within primary care doctor-patient consultations for patients with multiple chronic conditions. [PDF]
, 2020 Goal-setting is widely recommended for supporting patients with multiple long-term conditions. It involves a proactive approach to a clinical consultation, requiring doctors and patients to work together to identify patient’s priorities, values and ...
Ford, John +5 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell +3 more
wiley +1 more source
Ethical Issues: Ethics Consultation [PDF]
, 2003 EssayMaking decisions within the complexities of modern health care is not easy. This is especially true in a training environment. Ethical dilemmas often present themselves, and having a mechanism available to effectively address complex ethical issues ...
Fleming, David A.
core
BMC Medical Ethics, 2008 Background Few comparative studies of clinical ethics consultation practices have been reported. The objective of this study was to explore how American and Japanese experts analyze an Alzheimer's case regarding ethics consultation.
Kosugi Shinji +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Response to centre for data ethics and innovation consultation [PDF]
, 2018 In this response, we addressed the 8 questions for consultation. We first express our opinion in terms of the solutions the Centre provides to address these issues.
Crowcroft, Jon +7 more
core
BMC Medical Ethics, 2001 A decade ago, we reviewed the field of clinical ethics; assessed its progress in research, education, and ethics committees and consultation; and made predictions about the future of the field.
Pellegrino Edmund D +2 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source