Results 251 to 260 of about 159,255 (285)
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Ethidium bromide enhancement of frameshift mutagenesis caused by photoactivatable ethidium analogs
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1979Ethidium azide analogs (3-amino-8-azido-ethidium monoazide and ethidium diazide) have been developed as photosensitive probes in order to analyze directly the reversible in vivo interactions of ethidium bromide. Our preliminary observations [11], relating the mutagenic potential of the monoazide analog of ethidium, have been extended and refined, using
L W, Yielding +3 more
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An ethidium ion selective electrode and its application to DNA-ethidium binding
Biochemical and Biophysical Research Communications, 1981Abstract A liquid membrane electrode has been made which is selective for ethidium ion. The membrane is formed in a capillary by a 3-nitro-o-xylene solution of an ethidium-tetraphenyl borate complex. The electrode emf (vs saturated KCl-calomel reference) has a linear dependence upon the logarithm of ethidium concentration from 2 μM to 0.5 mM.
T N, Blanton +2 more
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Equilibrium studies of ethidium-polynucleotide interactions
Biochemistry, 1981We report equilibrium dialysis studies of the binding of ethidium to a variety of double-helical synthetic polynucleotides containing A.U (or T) and I.C base pairs. The results are interpreted in terms of the neighbor exclusion model of drug binding, with allowance both for cooperativity of binding and for a structural switch of the helix to a ...
J L, Bresloff, D M, Crothers
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Interaction of Ethidium Bromide with Heparin
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1975The reactions of hydrated electrons produced during pulse radiolysis have been utilized to investigate the binding of ethidium bromide to heparin. Complexes of ethidium bromide and heparin can be dissociated with salt. Divalent cations are more effective than monovalent cations in this respect.
S, Chaudhuri +3 more
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On the Electronic Structure of Ethidium
Chemistry – A European Journal, 2004AbstractThe electronic structure of the common intercalating agent ethidium bromide (3,8‐diamino‐5‐ethyl‐6‐phenylphenanthridinium bromide) is dominated by an interplay of electron donating and withdrawing effects mediated by its nitrogen atoms. X‐ray crystallography, UV/Vis and IR absorption, fluorescence emission, and NMR spectroscopy are used to ...
Nathan W, Luedtke, Qi, Liu, Yitzhak, Tor
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Unfolding of nucleosomes by ethidium binding
Biochemistry, 1980We report spectroscopic, hydrodynamic, and biochemical studies on the complex of ethidium bromide with 140 base pair nucleosomal core particles. Fluorescence titration indicates a greater intrinsic affinity of ethidium for nucleosomes than for DNA, and fluorescence depolarization measurements imply increased immobilization of ethidium bound to ...
H M, Wu +3 more
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Yeast mutants resistant to ethidium bromide
Molecular and General Genetics MGG, 1973Yeast mutants resistant to ethidium bromide have been isolated among sensitive grande cells (ϱ+) for their ability to grow on glycerol in the presence of the dye. Mutant cells are also resistant to acriflavin and do not yield petites (ϱ-) when grown on galactose with the mutagen.
M, Gouhier, J C, Mounolou
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A synthesis of labeled ethidium bromide
Archives of Biochemistry and Biophysics, 1974Abstract A method is described for the synthesis of labeled ethidium (3,8-diamino-5-ethyl-6-phenyl phenanthridinium) bromide. Based on benzoic acid, the radioactive precursor used, the yield is 15% of a compound that is indistinguishable from authentic ethidium bromide in its absorption spectra (uv, visible, ir), Chromatographie behavior, and ...
R, De Nobrega Bastos, H R, Mahler
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1979
Propidium, a phenanthridinium dye similar to ethidium, did not induce petite mutations in non-growing yeast cells in contrast to ethidium. Combined exposure to ethidium and an excess of propidium for periods up to 2 h resulted in the expected petite induction expressed after subsequent plating on growth medium.
M, Fukunaga, K L, Yielding
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Propidium, a phenanthridinium dye similar to ethidium, did not induce petite mutations in non-growing yeast cells in contrast to ethidium. Combined exposure to ethidium and an excess of propidium for periods up to 2 h resulted in the expected petite induction expressed after subsequent plating on growth medium.
M, Fukunaga, K L, Yielding
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Biochemical and Biophysical Research Communications, 1979
Abstract The photoreactive analogs of ethidium bromide (ethidium mono- and diazide) have been developed as drug probes to determine the actual molecular details of ethidium bromide interactions with DNA. In an effort to demonstrate that the analogs in fact mimic the parent ethidium, competition experiments were designed using 3H thymidine-labeled DNA
L W, Yielding +3 more
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Abstract The photoreactive analogs of ethidium bromide (ethidium mono- and diazide) have been developed as drug probes to determine the actual molecular details of ethidium bromide interactions with DNA. In an effort to demonstrate that the analogs in fact mimic the parent ethidium, competition experiments were designed using 3H thymidine-labeled DNA
L W, Yielding +3 more
openaire +2 more sources