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Synthesis of 6-14C-ethidium bromide
Analytical Biochemistry, 1972Abstract The preparation of 6- 14 C-ethidium bromide of high specific radioactivity is described. The synthesis starts from 14 C-carboxyl-labeled benzoic acid and 4,4′-dinitro-2-aminodiphenyl. The crude compound was purified by chromatography on aluminum oxide.
F J, Loomeijer, A M, Kroon
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Mutation Research/Environmental Mutagenesis and Related Subjects, 1978
The [14C]-labeled monoazido analog of ethidium, 3-amino-8-azido-5-ethyl-6-phenylphenanthridinium chloride, when mixed with yeast cells and photolyzed, produced covalent adducts with both nuclear and mitochondrial DNA via the light-generated nitrene. The binding efficiency was about 12 times higher in mitochondrial than nuclear DNA. Moreover, the parent
T, Morita, K L, Yielding
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The [14C]-labeled monoazido analog of ethidium, 3-amino-8-azido-5-ethyl-6-phenylphenanthridinium chloride, when mixed with yeast cells and photolyzed, produced covalent adducts with both nuclear and mitochondrial DNA via the light-generated nitrene. The binding efficiency was about 12 times higher in mitochondrial than nuclear DNA. Moreover, the parent
T, Morita, K L, Yielding
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Mitochondrial membranes and mutagenesis by ethidium bromide
Journal of Supramolecular Structure, 1972AbstractThe conversion of wild type (ρ+) to cytoplasmic petites (ρ−) in Saccharomyces cerevisiae, à mutation in mitochondrial DNA, can be brought about with high efficiency by low concentrations of ethidium bromide (EB). The rate and extent of mutagenesis and its expression can be influenced, and even reversed, by a number of genetic lesions, agents or
H R, Mahler, P S, Perlman
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1975
Ethidium and propidium (Fig. 1) are phenanthridinium compounds which have attracted a great deal of interest in recent years because of their usefulness as tools for the experimental study of nucleic acids. Of the two ethidium is much the best known since it is readily available and inexpensive, being a well-established drug in widespread use for the ...
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Ethidium and propidium (Fig. 1) are phenanthridinium compounds which have attracted a great deal of interest in recent years because of their usefulness as tools for the experimental study of nucleic acids. Of the two ethidium is much the best known since it is readily available and inexpensive, being a well-established drug in widespread use for the ...
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Inhibition of yeast sporulation by ethidium bromide
Molecular and General Genetics MGG, 1978Ethidium bromide blocks ascus formation in the yeast Saccharomyces cerevisiae. This may mean that the presence of the mitochondrial genome is required for sporulation in this organism.
M C, Newlon, B D, Hall
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Crystal structure of ethidium bromide
Journal of Crystal and Molecular Structure, 1971Crystals of ethidium bromide (2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide) monohydrate are monoclinic,a = 9·577,b = 10·698,c = 20·242 A, β = 106·34 °,Z = 4, space groupP21/c. The structure was determined with CuKα. diffractometer data by direct methods, and was refined by full-matrix least-squares methods toR = 0·058 for 2151 observed ...
E. Subramanian +2 more
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Decontamination of Ethidium Bromide Spills
Applied Industrial Hygiene, 1989Abstract Samples of stainless steel, Formica, glass, and vinyl floor tile and the filters of transilluminators were contaminated with ethidium bromide and cleaned either by wiping once with a paper towel soaked in an aqueous solution of sodium nitrite and hypophosphorous acid followed by five wipes with wet towels or by wiping six times with only wet ...
George Lunn, Eric B. Sansone
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Viscosity dependence of ethidium-DNA intercalation kinetics
Biochemistry, 1987The kinetics of ethidium intercalation into double-stranded poly[d(G-C)] were investigated by use of repetitive pressure-jump chemical relaxation at 20 degrees C in low ionic strength (0.1 M NaCl) aqueous buffers containing either glycerol or methanol.
MacGregor, R., Clegg, R., Jovin, T.
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Binding of ethidium bromide to fractionated chromatin
Experimental Cell Research, 1976Abstract The binding of ethidium bromide (EB) to different chromatin preparations was tested. Scatchard plots showed that the slowly sedimenting fraction of sheared chromatin is enriched in dye-binding sites. Limited nuclease digestion of rat liver nuclei, which has been shown to preserve the subunit structure of chromatin, reduces the number of ...
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