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Yeast mutants resistant to ethidium bromide
Molecular and General Genetics MGG, 1973Yeast mutants resistant to ethidium bromide have been isolated among sensitive grande cells (ϱ+) for their ability to grow on glycerol in the presence of the dye. Mutant cells are also resistant to acriflavin and do not yield petites (ϱ-) when grown on galactose with the mutagen.
M, Gouhier, J C, Mounolou
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2000
Abstract Ethidium bromide (EB), a phenanthridinium dye, is used as an antitrypanosomal drug in veterinary medicine and, in the research setting, as a membrane-permeant cell marker (11), a DNA stain, and an experimental arthropod and mammalian neurotoxin and cytotoxin. EB forms bitter-tasting, dark-red crystals with a
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Abstract Ethidium bromide (EB), a phenanthridinium dye, is used as an antitrypanosomal drug in veterinary medicine and, in the research setting, as a membrane-permeant cell marker (11), a DNA stain, and an experimental arthropod and mammalian neurotoxin and cytotoxin. EB forms bitter-tasting, dark-red crystals with a
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Binding of ethidium bromide to fractionated chromatin
Experimental Cell Research, 1976Abstract The binding of ethidium bromide (EB) to different chromatin preparations was tested. Scatchard plots showed that the slowly sedimenting fraction of sheared chromatin is enriched in dye-binding sites. Limited nuclease digestion of rat liver nuclei, which has been shown to preserve the subunit structure of chromatin, reduces the number of ...
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Crystal structure of ethidium bromide
Journal of Crystal and Molecular Structure, 1971Crystals of ethidium bromide (2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide) monohydrate are monoclinic,a = 9·577,b = 10·698,c = 20·242 A, β = 106·34 °,Z = 4, space groupP21/c. The structure was determined with CuKα. diffractometer data by direct methods, and was refined by full-matrix least-squares methods toR = 0·058 for 2151 observed ...
E. Subramanian +2 more
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Decontamination of Ethidium Bromide Spills
Applied Industrial Hygiene, 1989Abstract Samples of stainless steel, Formica, glass, and vinyl floor tile and the filters of transilluminators were contaminated with ethidium bromide and cleaned either by wiping once with a paper towel soaked in an aqueous solution of sodium nitrite and hypophosphorous acid followed by five wipes with wet towels or by wiping six times with only wet ...
George Lunn, Eric B. Sansone
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Ethidium bromide enhancement of frameshift mutagenesis caused by photoactivatable ethidium analogs
Mutation Research, 1979Ethidium azide analogs (3-amino-8-azido-ethidium monoazide and ethidium diazide) have been developed as photosensitive probes in order to analyze directly the reversible in vivo interactions of ethidium bromide. Our preliminary observations [11], relating the mutagenic potential of the monoazide analog of ethidium, have been extended and refined, using
L W, Yielding +3 more
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Metabolism of ethidium bromide in rats.
Drug Metabolism and Disposition, 1981The biliary excretion products recovered after iv administration of ethidium bromide to rats were found to consist of: unchanged drug, 8-acetylethidium, and an 8-acetylated hydroxylated metabolite. Proofs of structure were obtained by field desorption mass spectroscopy and 1H NMR, which indicated that the latter metabolite is probably substituted at ...
C, Fraire, P, Lecointe, C, Paoletti
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Synthesis of 6-14C-ethidium bromide
Analytical Biochemistry, 1972Abstract The preparation of 6- 14 C-ethidium bromide of high specific radioactivity is described. The synthesis starts from 14 C-carboxyl-labeled benzoic acid and 4,4′-dinitro-2-aminodiphenyl. The crude compound was purified by chromatography on aluminum oxide.
F J, Loomeijer, A M, Kroon
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Multiple interactions of ethidium bromide with yeast cells
Archives of Biochemistry and Biophysics, 1980Abstract Experiments were carried out to determine the relationship between different energy states of the yeast cell and the uptake of ethidium bromide (EB). By varying the substrate, oxygenation, and by the use of uncouplers or respiratory inhibitors, it is possible to have energization or not of the whole cell, and also to deenergize specifically ...
A, Peña +4 more
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