Results 101 to 110 of about 829,648 (303)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Ethiopian Journal of the Social Sciences and HumanitiesA review of major literature on conflict prevention reveals a lack of consensus on the subject matter. One strand of the debate revolves around whether conflict prevention should be limited solely to the early and non-escalatory stages of conflict, or it
Awet Halefom Kahsay
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Cogent Social SciencesSeveral interethnic violent conflicts have escalated in Ethiopia over the last few years. Particularly in the southern regional state of Ethiopia, the conflict between the Konso and Ale ethnic groups has its roots in intercommunal crises.
Mulumebet Major +4 more
doaj +1 more source
Greed and grievance in civil wars [PDF]
We investigate the causes of civil war, using a new data set of wars during 1960-99. We test a `greed’ theory focusing on the ability to finance rebellion, against a `grievance’ theory focusing on ethnic and religious divisions, political repression and ...
Anke Hoeffler, Paul Collier
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Why Do Ethnic Groups Rebel? New Data and Analysis [PDF]
, 2017 Much of the quantitative literature on civil wars and ethnic conflict ignores the role of the state or treats it as a mere arena for political competition among ethnic groups.
Cederman, Lars-Erik +2 more
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Ethnic Background of the Two Feeding Stories in Mark’s Gospel
ReligionsThe analysis delves into the conflict inherent within the thematic discourse surrounding the two tables as portrayed in Mark’s Gospel, with particular emphasis on the section concerning the multiplication of loaves of bread (Mk 6–8).
Paula Andrea García Arenas
doaj +1 more source
Death as a measure of duration of conflict [PDF]
This paper argues that number of deaths in a conflict can be a measure of duration and demonstrates that there are information gains to this approach.
Ayla Ogus, Sacit Hadi Akdede
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