Results 61 to 70 of about 829,648 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multidimensional factors contributing to the dynamics of ethnic conflict in Ethiopia

Cogent Social Sciences
In Ethiopia, ethnic federalism was implemented in the 1990s with the intention of redressing past marginalization, in which certain groups were excluded from political participation, economic prospects, and cultural acknowledgement.
Keneni Jibat, Yonas Aday Adeto, Taddesse Berisso Galchu   +2 more
doaj   +1 more source

Pamięć jako narzędzie walki w konfliktach etnicznych

Politeja, 2014
Is Social Memory used as a Weapon in Ethnic Conflicts? Northern Ireland Casus In case of ethnic conflicts, groups may use memories or symbols of casualties or events which happened during conflict, as a specific symbolic weapon. Weapon addressed to the
Ewa Szczecińska-Musielak
doaj   +1 more source

Ethnic polarization, potential conflict and civil wars [PDF]

This paper analyzes the relationship between ethnic fractionalization, polarization, and conflict. In recent years many authors have found empirical evidence that ethnic fractionalization has a negative effect on growth.
José Garcia Montalvo, Marta Reynal-Querol   +1 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Unheard Voices: Roma and the Kosovo War

Kultura (Skopje), 2014
The Kosovo conflict is usually seen – and remembered – as a conflict between ethnic Serbs and ethnic Albanians. It was the escalating armed conflict between these two ethnic groups following the revoking of Kosovo’s autonomy by the Miloševič regime in ...
Rainer Schulze
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

War signals: a theory of trade, trust and conflict [PDF]

We construct a dynamic theory of civil conflict hinging on inter-ethnic trust and trade. The model economy is inhabitated by two ethnic groups. Inter-ethnic trade requires imperfectly observed bilateral investments and one group has to form beliefs on ...
Dominic Rohner, Fabrizio Zilibotti, Mathias Thoenig   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Vetoes, Ethnic Bidding, Decentralisation: Post-Conflict Education in Macedonia [PDF]

Journal on Ethnopolitics and Minority Issues in Europe, 2012
This article focuses on political elites in post-conflict Macedonia and investigates how political elites interact - to accomodate or resist each other - across ethnic lines.
Cvete Koneska
doaj