Results 41 to 50 of about 155,829 (259)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

TOLERANCE AND COEXISTENCE OF SOCIAL GROUPS IN THE WORKS OF REINHOLD NIEBUHR

Освітній дискурс, 2020
The article shows the nature of conflicts between social groups in society according to the position of Reinhold Niebuhr’s Christian realism. The nature of conflicts between religious groups, ethnic groups and economic classes is described.
Vitalii Brynov
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Multidimensional factors contributing to the dynamics of ethnic conflict in Ethiopia

Cogent Social Sciences
In Ethiopia, ethnic federalism was implemented in the 1990s with the intention of redressing past marginalization, in which certain groups were excluded from political participation, economic prospects, and cultural acknowledgement.
Keneni Jibat, Yonas Aday Adeto, Taddesse Berisso Galchu   +2 more
doaj   +1 more source

MAJOR THEORETICAL APPROACHES TO CONSTRUCTIVE CONFLICT RESOLUTION IN THE NORTH CAUCASUS

Politologija, 2017
This article explores the major approaches to the study of conflict resolution strategy from a variety of interdisciplinary perspectives. It argues that conflict resolution strategy, as a civil integration resource, is a necessary tool for overcoming ...
Maxim Popov
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

National Conflicts in North Caucasus: Origins and Resolution

Научный диалог
This article examines the causes and consequences of national conflicts in the North Caucasus. It addresses issues related to the sources of ethnic conflicts in contemporary times.
M. S. Sevinj
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Ethnic and Religious Aspects in the Study of Terrorism

Èkonomika, Pedagogika i Pravo, 2016
The article explains the importance of ethnic and religious aspects in the study of the nature of terrorist violence. It is emphasized that in the regions covered by ethnic conflicts, terrorist methods of struggle manifest themselves very significant and
Zoya Sh. Matchanova
doaj